AT 7867

Catalog # Availability Size / Price Qty
7001/50
7001/10
AT 7867 | CAS No. 2624336-89-4 | Akt (Protein Kinase B) Inhibitors
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Description: Potent pan-Akt and PKA inhibitor

Chemical Name: 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC50 values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively). Also inhibits p70-S6 kinase (p70S6K, IC50 = 85 nM). Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon. Promotes proliferation of iPSC-derived PDX1+ pancreatic progenitor cells (PPCs).

Technical Data

M.Wt:
374.31
Formula:
C20H20ClN3.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2624336-89-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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