Atosiban

Catalog #: 6332
4 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6332/10

1 Image

Description: Potent oxytocin receptor antagonist

Purity: ≥98%

View All Products for Oxytocin Receptor Antagonists

Product Details

Citations (4)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Atosiban is a potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca²⁺ concentration in myometrial cells in vitro (IC₅₀ = 5 nM) Activates NF-κB and MAPK pathways in human amnion via G_αi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.

Technical Data

M.Wt:

994.19

Formula:

C₄₃H₆₇N₁₁O₁₂S₂

Sequence:

XYITNCPXG

(Modifications: X-1 = Mpr, Tyr-2 = D-Tyr(OEt), X-8 = Orn, Gly-9 = C-terminal amide, Cyclized: X-1 - Cys-6)

Solubility:

Soluble to 50 mg/ml in water

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

90779-69-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The oxyt. receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G_αi signalling.
Kim et al.
Mol.Cell.Endocrinol., 2016;420:11
Differential effects of oxyt. receptor antagonists, Atosiban and Nolasiban, on oxyt. receptor-mediated signaling in human amnion and myometrium.
Kim et al.
Mol.Pharmacol., 2017;91:403
Evaluation of 1-deamino-[D-Tyr(Oethyl)², Thr⁴, Orn⁸] vasotocin, an oxyt. antagonist, in animal models of uterine contractility and preterm labor: a new tocolytic agent.
Hahn et al.
Am.J.Obstet.Gynecol., 1987;157:977
Antagonists for the human oxyt. receptor: an in vitro study.
Maggi et al.
J.Reprod.Fertil., 1994;101:345

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Atosiban

The citations listed below are publications that use Tocris products. Selected citations for Atosiban include:

4 Citations: Showing 1 - 4

Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: evidence from Gapmer-induced exon skipping.
Authors: Silke Et al.
Front Cell Neurosci 2022;16:1000538
Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia.
Authors: Xiaobing Et al.
Neuropsychopharmacology 2021;46:1045-1056
Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation
Authors: Li Et al.
Cell Rep 2021;36:109411
Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain Following Infraorbital Nerve Injury in Rats.
Authors: Yoshiyuki Et al.
Int J Mol Sci 2020;21

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Atosiban

There are currently no reviews for this product. Be the first to review Atosiban and earn rewards!

Have you used Atosiban?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.