Autocamtide-2-related inhibitory peptide
Purity: ≥95%
Biological Activity
Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).Cell permeable derivative also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.
Ishida et al.
Biochem.Biophys.Res.Commun., 1995;212:806 -
Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain.
Ishida and Fujisawa
J.Biol.Chem., 1995;270:2163 -
Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization.
Takasawa et al.
J.Biol.Chem., 1995;270:30257
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Citations for Autocamtide-2-related inhibitory peptide
The citations listed below are publications that use Tocris products. Selected citations for Autocamtide-2-related inhibitory peptide include:
2 Citations: Showing 1 - 2
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Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit.
Authors: Cho Et al.
J Neurosci 2012;32:14165
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Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.
Authors: Grey and Burrell
J Neurophysiol 2010;103:2737
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