AZ 20

Catalog # Availability Size / Price Qty
5198/10
5198/50
AZ 20 | CAS No. 1233339-22-4 | ATM and ATR Kinase Inhibitors
1 Image
Description: Potent and selective ATR kinase inhibitor; antitumor

Chemical Name: 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole

Purity: ≥98%

Product Details
Citations (8)
Reviews

Biological Activity

AZ 20 is a potent and selective ATR kinase inhibitor (IC50 = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.

Technical Data

M.Wt:
412.51
Formula:
C21H24N4O3S
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1233339-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for AZ 20

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AZ 20

There are currently no reviews for this product. Be the first to review AZ 20 and earn rewards!

Have you used AZ 20?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.