AZ 20

Catalog #: 5198
8 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5198/10
5198/50

AZ 20 | CAS No. 1233339-22-4 | ATM and ATR Kinase Inhibitors

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Description: Potent and selective ATR kinase inhibitor; antitumor

Chemical Name: 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole

Purity: ≥98%

View All Products for ATM and ATR Kinase Inhibitors

Product Details

Citations (8)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AZ 20 is a potent and selective ATR kinase inhibitor (IC₅₀ = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.

Technical Data

M.Wt:

412.51

Formula:

C₂₁H₂₄N₄O₃S

Solubility:

Soluble to 50 mM in DMSO and to 10 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1233339-22-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from AstraZeneca

Background References

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
Foote et al.
J.Med.Chem., 2013;56:2125

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for AZ 20

The citations listed below are publications that use Tocris products. Selected citations for AZ 20 include:

8 Citations: Showing 1 - 8

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity.
Authors: Daniel Et al.
Oncotarget 2022;13:332-346
MYBL2 and ATM suppress replication stress in pluripotent stem cells.
Authors: George Et al.
EMBO Rep 2021;22:e51120
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration.
Authors: Jiri Et al.
Nat Commun 2020;11:4828
Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments.
Authors: Kilic Et al.
EMBO J 2019;:e101379
Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability.
Authors: Teloni Et al.
Mol Cell 2019;73:670
A Compendium of Mutational Signatures of Environmental Agents.
Authors: Stephen P Et al.
Cell 2019;177:821-836.e16
BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication.
Authors: Bowry Et al.
Cell Rep 2018;25:2061
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.
Authors: Skau Et al.
Cell 2016;167:1571

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