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AZD 7648

Catalog #: 7825 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7825/50
7825/10
AZD 7648 | CAS No. 2230820-11-6 | DNA-dependent Protein Kinase Inhibitors
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Description: Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency

Chemical Name: 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one

Purity: ≥98%

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Biological Activity

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable. AZD 7648 also enhances CRISPR-mediated HDR efficiency.

Technical Data

M.Wt:
380.41
Formula:
C18H20N8O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2230820-11-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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