Azimilide dihydrochloride
Chemical Name: 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride
Purity: ≥97%
Biological Activity
Azimilide dihydrochloride is a Kv11.1 (hERG) channel blocker, blocks rapidly activating and slowly activating components of delayed rectifier K+ currents (IC50 of 0.4 mM and 3 mM, respectively). Also inhibits Na+/Ca2+ exchanger in vitro. Shows inhibition of Na+ currents, L-type Ca2+ currents and other K+ currents at high concentrations.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibitory Effect of Azimilide on Na+/Ca2+ Exchange Current in Guinae-Pig Cardiac Myocytes.
Watanabe and Kimura
J.Pharmacol.Sci., 2010;114:111 -
Blockade of HERG channels by the class III antiarrhythmic Azimilide: mode of action.
Busch et al.
Br.J.Pharmacol., 1998;123:23 -
Blockade of Human IsK channels expression in Xenopus oocytes by the novel class III antiarrhythmic NE-10064.
Busch et al.
Eur.J.Pharmacol., 1995;264:33 -
Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarisation: block of delayed rectifier potassium and L-type calcium currents.
Fermini et al.
J.Cardiovasc.Pharmacol., 1995;26:259
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