Home / Guanylyl Cyclase Activators / BAY 41-2272

BAY 41-2272

Catalog #: 4430
1 Citation Datasheet / COA / SDS
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4430/10
4430/50
BAY 41-2272 | CAS No. 256376-24-6 | Guanylyl Cyclase Activators
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Description: Soluble guanylyl cyclase (sGC) activator

Chemical Name: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Technical Data

M.Wt:
360.39
Formula:
C20H17FN6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
256376-24-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for BAY 41-2272

The citations listed below are publications that use Tocris products. Selected citations for BAY 41-2272 include:

1 Citation: Showing 1 - 1

  1. Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.
    Authors: Aly Et al.
    Cell Rep  2019;27:1769-1780.e4

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