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BCI

Catalog #: 7481 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7481/50
BCI | CAS No. 15982-84-0 | MKP-1
1 Image
Description: DUSP6 and DUSP1 inhibitor

Chemical Name: 3-(Cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1H-inden-1-one

Purity: ≥98%

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Biological Activity

BCI is an allosteric inhibitor of dual specificity phosphatase DUSP6 and DUSP1 (EC50 values are 8.0 μM and 13.3 μM respectively). Increases P2X7 receptor expression in neuroblastoma cells, reduces cell viability of EGFR or KRAS mutant lung cancer cells, and induces apoptosis in p53-null non-small cell lung cancer cells. In an animal model of myocardial infarction, BCI improves heart function, reduces fibrosis, and reduces inflammation by inhibiting macrophage formation. Activates FGF signaling in zebrafish embryo development to increase myocardial progenitor population and heart size.

Technical Data

M.Wt:
317.42
Formula:
C22H23NO
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
15982-84-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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