Bepridil hydrochloride
Chemical Name: N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride
Purity: ≥99%
Biological Activity
Bepridil hydrochloride is a calcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacology of bepridil.
Gill et al.
Am.J.Cardiol., 1992;69:11D -
Bepridil block of cardiac calcium and sodium channels.
Yatani et al.
J.Pharmacol.Exp.Ther., 1986;237:9 -
Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes.
Wantanabe and Kimura
Jpn.J.Pharmacol., 2001;85:370 -
Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.
Sato et al.
J.Pharmacol.Exp.Ther., 2006;316:182
Product Datasheets
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Citations for Bepridil hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Bepridil hydrochloride include:
3 Citations: Showing 1 - 3
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Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells.
Authors: Xiaoli Et al.
Int J Mol Sci 2022;23
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Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death.
Authors: Yan Et al.
Br J Pharmacol 2019;176:2691-2707
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Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities.
Authors: Ciapa and Philippe
PLoS One 2013;8:e66113
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