BGP 15

Biological Activity

BGP 15 is a PARP inhibitor (IC₅₀ = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. BGP 15 also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.
   Henstridge et al.
   Diabetes., 2014;63:1881
2. BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia.
   Ohlen et al.
   Proc.Natl.Acad.Sci.U.S.A, 2017;114:5035
3. HSP72 protects against obesity-induced insulin resistance.
   Chung et al.
   Proc.Natl.Acad.Sci.U.S.A, 2008;105:1739
4. BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase.
   Szabados et al.
   Biochem.Pharmacol., 2000;59:937
5. BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity.
   Racz et al.
   Biochem.Pharmacol., 2002;63:1099

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