Home / Bromodomain Inhibitors / BI 9564

BI 9564

Catalog #: 5590
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5590/10
BI 9564 | CAS No. 1883429-22-8 | Bromodomain Inhibitors
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Description: Potent and selective BRD9 and BRD7 inhibitor; orally active

Chemical Name: 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

BI 9564 is a potent and selective BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI-9564 is reviewed on the chemical probes website.

Technical Data

M.Wt:
353.41
Formula:
C20H23N3O3
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1883429-22-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9564 probe summary on the SGC website.

Background References

  1. An Advanced Tool To Interrogate BRD9.
    Karim and Schönbrunn
    J.Med.Chem., 2016;59:4459
  2. Structure-based design of an in vivo active selective BRD9 inhibitor
    Martin et al.
    J.Med.Chem., 2016;59:4462

Product Datasheets

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Reconstitution Calculator

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Citation for BI 9564

The citations listed below are publications that use Tocris products. Selected citations for BI 9564 include:

1 Citation: Showing 1 - 1

  1. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4.
    Authors: Nasun Et al.
    Proc Natl Acad Sci U S A  2022;119

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