(-)-Bicuculline methobromide

Catalog #: 0109
15 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0109/10
0109/50

(-)-Bicuculline methobromide | CAS No. 66016-70-4 | GABA-A Receptor Antagonists

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Description: GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)

Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide

Purity: ≥98%

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Product Details

Citations (15)

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Biological Activity

(-)-Bicuculline methobromide is a methobromide salt of (+)-bicuculline. Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

Methoiodide Salt and Methochloride Salt also available.

Technical Data

M.Wt:

462.3

Formula:

C₂₁H₂₀BrNO₆

Solubility:

Soluble to 50 mM in water

Purity:

≥98%

Storage:

Store at RT

CAS No:

66016-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

Recent advances in the pharmacology of quaternary salts of bicuculline.
Seutin and Johnson
TiPS, 1999;20:268
Characteristics of GABA_B receptor binding sites on rat whole brain synaptic membranes.
Bowery et al.
Br.J.Pharmacol., 1983;78:191
Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats.
Sperber et al.
Brain Res., 1987;465:243

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Citations for (-)-Bicuculline methobromide

The citations listed below are publications that use Tocris products. Selected citations for (-)-Bicuculline methobromide include:

15 Citations: Showing 1 - 10

Social modulation during songbird courtship potentiates midbrain DArgic neurons.
Authors: Huang and Hessler
PLoS One ;3:e3281
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Authors: Woo Et al.
Exp Neurobiol 2019;28:30
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Authors: Nam Et al.
Cell Rep 2019;28:1154
Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations.
Authors: Chen Et al.
Neuron 2017;96:1403
Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.
Authors: Andrade-Talavera Et al.
Cereb Cortex 2016;26:3637
Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
Neuroscience 2015;290:332
Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.
Authors: Maccione Et al.
J Physiol 2014;592:1545
Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol.
Authors: Maguire Et al.
Neuropsychopharmacology 2014;39:1232
Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.
Authors: Johnson Et al.
Neurosci Lett 2011;504:102
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
Authors: Galván Et al.
J Neurosci 2010;30:2844

Postsynaptic spiking homeostatically induces cell-autonomous regulation of inhibitory inputs via retrograde signaling.
Authors: Peng Et al.
J Neurosci 2010;30:16220

Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
Authors: Sipilä Et al.
J Neurosci 2009;29:6982

GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
Authors: Miyazato Et al.
J Urol 2008;179:1178

Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex.
Authors: Krook-Magnuson Et al.
J Neurophysiol 2008;100:932

GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
Authors: Gascon Et al.
J Neurosci 2006;26:12956

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