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Biperiden hydrochloride

Catalog #: 2853 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2853/10
2853/50
Biperiden hydrochloride | CAS No. 1235-82-1 | mAChR M1 Antagonists
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Description: Muscarinic receptor antagonist; some selectivity for M1
Alternative Names: Akineton

Chemical Name: α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol hydrochloride

Purity: ≥99%

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Biological Activity

Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.

Technical Data

M.Wt:
347.92
Formula:
C21H29NO.HCl
Solubility:
Soluble to 5 mM in water and to 10 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
1235-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells.
    Bolden et al.
    J.Pharmacol.Exp.Ther., 1992;260:576
  2. Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective.
    Brocks
    J.Pharm.Pharmaceut.Sci., 1999;2:39
  3. Muscarinic receptor occupancy by bipe. in living human brain.
    Sudo et al.
    Life Sci., 1999;64:PL99

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