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Bisindolylmaleimide II

Catalog #: 4128
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4128/10
4128/50
Bisindolylmaleimide II | CAS No. 137592-45-1 | Protein Kinase C Inhibitors
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Description: Potent PKC inhibitor; also potent nAChR antagonist

Chemical Name: 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione

Purity: ≥97%

Product Details
Citations (4)
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Biological Activity

Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 0.01 μM). Displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50 values are 0.75 and 2μM for PK and PKA respectively). Also displays potent, noncompetitive antagonism at nicotinic cholinergic receptors (IC50 ~ 0.03 μM for inhibition of catecholamine secretion in nicotine-stimulated PC-12 cells).

Technical Data

M.Wt:
438.52
Formula:
C27H26N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
137592-45-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Bisindolylmaleimide II

The citations listed below are publications that use Tocris products. Selected citations for Bisindolylmaleimide II include:

4 Citations: Showing 1 - 4

  1. Contributing mechanisms underlying desensitization of cholecystokinin-induced activation of primary nodose ganglia neurons.
    Authors: James H Et al.
    Am J Physiol Cell Physiol  2020;318:C787-C796
  2. Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis.
    Authors: John Et al.
    ACS Chem Biol  2020;15:1212-1221
  3. Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C.
    Authors: O'Neill & Sylantyev
    Exp Biol Med (Maywood)  2018;243:1046
  4. Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
    Authors: Jones Et al.
    PLoS One  2004;279:40475

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