BMS 566419

Catalog #: 5492 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
5492/10
5492/50

BMS 566419 | CAS No. 566161-24-8 | Dehydrogenase Inhibitors

1 Image

Description: Inosine monophosphatase dehydrogenase (IMPDH) inhibitor

Chemical Name: N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide

Purity: ≥98%

View All Products for Dehydrogenase Inhibitors

Product Details

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC₅₀ = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Technical Data

M.Wt:

487.57

Formula:

C₂₈H₃₀FN₅O₂

Solubility:

Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

566161-24-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Watterson et al.
J.Med.Chem., 2007;50:3730

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BMS 566419

There are currently no reviews for this product. Be the first to review BMS 566419 and earn rewards!

Have you used BMS 566419?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.