BOP
Chemical Name: N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Purity: ≥98%
Biological Activity
BOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.
High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist.
Cao et al.
Nat.Commun., 2016;7:11007 -
Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells.
Cao et al.
Org.Biomol.Chem., 2014;12:965 -
Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1.
Pepinsky et al.
Biochemistry, 2002;41:7125
Product Datasheets
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Citations for BOP
The citations listed below are publications that use Tocris products. Selected citations for BOP include:
4 Citations: Showing 1 - 4
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Plasma cell dynamics in the bone marrow niche.
Authors: David R Et al.
Cell Rep 2021;34:108733
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Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression.
Authors: Jingping Et al.
EMBO Mol Med 2021;13:e13270
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Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma.
Authors: Uwe Et al.
Cancer Immunol Res 2020;8:1122-1138
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Intravital imaging reveals motility of adult hematopoietic stem cells in the bone marrow niche
Authors: Upadhaya Et al.
Cell Stem Cell 2020;27:336
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