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BTB1

Catalog #: 5399 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5399/10
5399/50
BTB1 | CAS No. 86030-08-2 | Kinesin Inhibitors
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Description: Selective and ATP-competitive Kif18A inhibitor

Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene

Purity: ≥99%

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Biological Activity

BTB1 is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.

Technical Data

M.Wt:
297.71
Formula:
C12H8ClNO4S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
86030-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A.
    Braun et al.
    ACS Chem.Biol., 2014;10:554
  2. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.
    Catarinella et al.
    Angew.Chem.Int.Ed.Engl., 2009;48:9072

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