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BzATP triethylammonium salt

Catalog #: 3312
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3312/1
BzATP triethylammonium salt | P2X Receptor Agonists
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Description: Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

Chemical Name: 2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphate tri(triethylammonium) salt

Purity: ≥95%

Product Details
Citations (6)
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Biological Activity

BzATP triethylammonium salt is a prototypic P2X7 receptor agonist (EC50 values are 3.6, 7 and 285 μM for rat, human and mouse receptors respectively). Exhibits 5 - 10 fold greater potency than ATP. Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.

This compound is a mixture of isomers.

Technical Data

M.Wt:
1018.97
Formula:
C24H24N5O15P3.C18H45N3
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 5mM)
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • This compound is a mixture of isomers

Product Datasheets

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Citations for BzATP triethylammonium salt

The citations listed below are publications that use Tocris products. Selected citations for BzATP triethylammonium salt include:

6 Citations: Showing 1 - 6

  1. Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury.
    Authors: Pronin Et al.
    Front Mol Neurosci  2019;12:36
  2. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.
    Authors: Karmakar Et al.
    Nat.Commun.  2016;7:10555
  3. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.
    Authors: Shabir Et al.
    Sci Rep  2013;305:F396
  4. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
    Authors: Ilatovskaya Et al.
    Am J Physiol Cell Physiol  2013;305:C1050
  5. Positive allosteric modulation by iverm. of human but not murine P2X7 receptors.
    Authors: Nörenberg Et al.
    Br J Pharmacol  2012;167:48
  6. Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors.
    Authors: Woehrle Et al.
    J Leukoc Biol  2010;88:1181

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