c-Di-AMP sodium salt
Chemical Name: 3',5'-Cyclic diadenylic acid sodium salt
Purity: ≥98%
Biological Activity
c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34+ cells.This product is sold in units of 702μg, equivalent to 1μmol.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- This product is sold in units of 702μg, equivalent to 1μmol.
Background References
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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response.
Parvatiyar et al.
Nat.Immunol., 2012;13:1155 -
Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death.
Tosolini et al.
Mol.Cell.Biol., 2015;35:479
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