c-Di-GMP sodium salt
Chemical Name: 3',5'-Cyclic diguanylic acid sodium salt
Purity: ≥98%
Biological Activity
c-Di-GMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.This product is sold in units of 730μg, equivalent to 1μmol.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- This product is sold in units of 730μg, equivalent to 1μmol.
Background References
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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response.
Parvatiyar et al.
Nat.Immunol., 2012;13:1155 -
STING is a direct innate immune sensor of cyclic di-GMP.
Burdette et al.
Nature, 2011;478:515 -
Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma.
Nakamura et al.
J.Control Release, 2015;216:149
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