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CA 074

Catalog #: 4863
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4863/1
CA 074 | CAS No. 134448-10-5 | Synthetic Cathepsin Inhibitors
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Description: Selective cathepsin B inhibitor

Chemical Name: N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CA 074 is an inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Technical Data

M.Wt:
383.44
Formula:
C18H29N3O6
Solubility:
Soluble to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
134448-10-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

    PLoS Pathog, 2016;12(7):e1005738.
  2. Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release
    C Szot, S Saha, XM Zhang, Z Zhu, MB Hilton, K Morris, S Seaman, JM Dunleavey, KS Hsu, GJ Yu, H Morris, DA Swing, DC Haines, Y Wang, J Hwang, Y Feng, D Welsch, G DeCrescenz, A Chaudhary, E Zudaire, DS Dimitrov, B St Croix
    J. Clin. Invest., 2018;0(0):.
  3. Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells.
    Gillet et al.
    J.Biol.Chem., 2009;284:8680
  4. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
    Towatari et al.
    FEBS Lett., 1991;280:311
  5. Cathepsin B inhibition limits bone metastasis in breast cancer.
    Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, Bidwell B, Edgington L, Wang L, Moin K, Sloane B, Anderson R, Bogyo M, Parker B
    Cancer Res, 2012-01-19;72(5):1199-209.

Product Datasheets

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Citations for CA 074

The citations listed below are publications that use Tocris products. Selected citations for CA 074 include:

3 Citations: Showing 1 - 3

  1. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy.
    Authors: Hong Et al.
    EMBO Mol Med  2022;14:e14511
  2. Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
    Authors: Eric Et al.
    Dev Cell  2019;49:393-408.e7
  3. C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death.
    Authors: Li Et al.
    Protein Cell  2018;9:1013

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