cAMPS-Sp, triethylammonium salt
Chemical Name: (S)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium
Purity: ≥98%
Biological Activity
cAMPS-Sp, triethylammonium salt is a cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor.R-enantiomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.
Dostmann et al.
J.Biol.Chem., 1990;265:10484 -
A family of cAMP-binding proteins that directly activate Rap1.
Kawasaki et al.
Science, 1998;282:2275 -
Ethanol inhibition of NMDA-induced responses and actute tolerance to the inhibition in rat rostral ventrolateral medulla in vivo: Involvement of cAMP-dependent protein kinases.
Lin et al.
Neuropharmacology, 2006;51:747 -
A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase.
O'Brian et al.
Biochemistry, 1982;21:4371
Product Datasheets
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Citations for cAMPS-Sp, triethylammonium salt
The citations listed below are publications that use Tocris products. Selected citations for cAMPS-Sp, triethylammonium salt include:
2 Citations: Showing 1 - 2
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Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer.
Authors: Mishra Et al.
Clin Cancer Res 2018;24:1987
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Dual regulation by ethanol of the inhibitory effects of KA on spinal NMDA-induced pressor responses in rats.
Authors: Keng Et al.
J Biomed Sci 2012;19:11
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