Canine CCR4 (NP_001003020) VersaClone cDNA

Canine CCR4 (NP_001003020) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: CCR4

CCR4 is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. Human CCR4 is 360 amino acids (aa) in length with a predicted molecular weight of 41 kDa. Mouse and rat CCR4 share 87% aa sequence identity with the human protein. Most chemokine receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. Chemokine ligand receptor binding results in G protein activation as well as the activation of downstream signaling cascades, including the Akt and NFkB pathways. Chemokine receptors mediate the chemotactic actions of chemokine ligands and activation of these receptors leads to cytoskeleton rearrangement and chemotactic cell migration.

Related Research Areas

• CC Chemokines and Receptors
• Chemokine Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• G Protein-Coupled Receptors in Immune Responses
• Platelet Cytokine and Growth Factor Receptors
• Regulatory T Cells (Tregs)
• T Cell Migration/Adhesion
• Th17 Cells
• Th2 Cells
• Th22 Cells