Home / Non-selective Cannabinoid Receptor Antagonists / (-)-Cannabidiol

(-)-Cannabidiol

Catalog #: 1570
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1570/10
1570/50
(-)-Cannabidiol | CAS No. 13956-29-1 | Non-selective Cannabinoid Receptor Antagonists
1 Image
Description: Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor
Alternative Names: CBD

Chemical Name: 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(-)-Cannabidiol is a non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB1 antagonist (IC50 values are 0.445 and 3.35 μM), CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50 = 27.5 μM). Also inhibits FABPs and a weak agonist at TRP vanilloid receptors (EC50 = 3.5 μM).

Technical Data

M.Wt:
314.47
Formula:
C21H30O2
Solubility:
Soluble to 75 mM in ethanol and to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
13956-29-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for (-)-Cannabidiol

The citations listed below are publications that use Tocris products. Selected citations for (-)-Cannabidiol include:

5 Citations: Showing 1 - 5

  1. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
    Authors: Panja Et al.
    Neuropathol Appl Neurobiol  2019;45:141
  2. Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
    Authors: Rodríguez-Muñoz Et al.
    Mol Brain  2018;11:51
  3. Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
    Authors: Esposito Et al.
    Proc Natl Acad Sci U S A  2011;6:e28668
  4. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
    Authors: Hamtiaux Et al.
    PLoS One  2011;6:e26823
  5. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.
    Authors: Whyte Et al.
    PLoS One  2009;106:16511

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for (-)-Cannabidiol

There are currently no reviews for this product. Be the first to review (-)-Cannabidiol and earn rewards!

Have you used (-)-Cannabidiol?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.