Carvedilol
Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Purity: ≥98%
Biological Activity
Carvedilol is a potent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region.
Kikuta et al.
Eur.J.Pharmacol., 2006;529:47 -
Differential effects of bucindolol and carve. on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats.
Ponicke et al.
J.Pharmacol.Exp.Ther., 2002;301:71
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Carvedilol
The citations listed below are publications that use Tocris products. Selected citations for Carvedilol include:
3 Citations: Showing 1 - 3
-
Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
Authors: Zaytseva Et al.
Sens Actuators B Chem 2013;188
-
Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
Authors: Baker Et al.
FASEB J 2011;25:4486
-
Blockade of adrenoreceptors inhibits the splenic response to stroke.
Authors: Ajmo Et al.
Nat Commun 2009;218:47
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Carvedilol
There are currently no reviews for this product. Be the first to review Carvedilol and earn rewards!
Have you used Carvedilol?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image