CC 401 dihydrochloride

Catalog # Availability Size / Price Qty
6258/10
6258/50
CC 401 dihydrochloride | CAS No. 2250025-96-6 | JNK/c-jun Inhibitors
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Description: High affinity JNK inhibitor; also inhibits HCMV replication

Chemical Name: 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole dihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

CC 401 dihydrochloride is a high affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication.

Technical Data

M.Wt:
461.39
Formula:
C22H24N6O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2250025-96-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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