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CDDO Im

Catalog #: 4737
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4737/10
CDDO Im | CAS No. 443104-02-7 | Nrf2 Activators
1 Image
Description: Nrf2 signaling activator

Chemical Name: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole

Purity: ≥98%

Product Details
Citations (4)
Reviews
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Biological Activity

CDDO Im is an Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. CDDO Im inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro. Also reduces acetaminophen-induced liver injury in mice.

Technical Data

M.Wt:
541.72
Formula:
C34H43N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
443104-02-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CDDO Im

The citations listed below are publications that use Tocris products. Selected citations for CDDO Im include:

4 Citations: Showing 1 - 4

  1. Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice.
    Authors: Thomas W Et al.
    Kidney Int  2021;99:102-116
  2. NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion.
    Authors: Kyung-Hyun Et al.
    Cells  2020;9
  3. Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome.
    Authors: Jörn Et al.
    Dev Cell  2018;46:145-161.e10
  4. Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice.
    Authors: Chartoumpekis Et al.
    Am J Physiol Endocrinol Metab  2018;315:E180

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