Home / Brutons Tyrosine Kinase (BTK) Inhibitors / CGI 1746

CGI 1746

Catalog #: 6965 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6965/50
6965/10
CGI 1746 | CAS No. 910232-84-7 | Brutons Tyrosine Kinase (BTK) Inhibitors
1 Image
Description: Potent, reversible BTK inhibitor

Chemical Name: N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide

Purity: ≥97%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC50 = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC50 values are 36 nM, 47 nM and 353 nM, respectively).

Technical Data

M.Wt:
579.7
Formula:
C34H37N5O4
Solubility:
Soluble to 20 mM in ethanol and to 5 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
910232-84-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CGI 1746

There are currently no reviews for this product. Be the first to review CGI 1746 and earn rewards!

Have you used CGI 1746?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.