CGRP 8-37 (rat)

Catalog #: 1169
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1169/500U

1 Image

Description: CGRP antagonist

Alternative Names: Calcitonin Gene-Related Peptide 8-37 (rat)

Purity: ≥95%

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Product Details

Citations (5)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CGRP 8-37 (rat) is a peptide antagonist for CGRP₁ receptors.

Technical Data

M.Wt:

3127.5

Formula:

C₁₃₈H₂₂₄N₄₂O₄₁

Sequence:

VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modification: Phe-30 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

129121-73-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacology of receptors for calcitonin gene-related peptide and amylin.
Poyner
TiPS, 1995;16:424
Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides.
Poyner et al.
Br.J.Pharmacol., 1998;124:1659
Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens.
Wisskirchen et al.
Br.J.Pharmacol., 1998;123:1673

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CGRP 8-37 (rat)

The citations listed below are publications that use Tocris products. Selected citations for CGRP 8-37 (rat) include:

5 Citations: Showing 1 - 5

Role of intraganglionic transmission in the trigeminovascular pathway.
Authors: Zhang Et al.
Mol Pain 2019;15:1744806919836570
Optogenetic Inhibition of CGRPα Sensory Neurons Reveals Their Distinct Roles in Neuropathic and Incisional Pain.
Authors: Cowie Et al.
J Neurosci 2018;38:5807
Critical role of calcitonin gene-related peptide receptors in cortical spreading depression.
Authors: Tozzi Et al.
Proc Natl Acad Sci U S A 2012;109:18985
Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1.
Authors: Khodorova Et al.
J Pain 2009;10:740
Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
Authors: Holland Et al.
J Cell Mol Med 2005;315:1380

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