Home / Calcium Binding Protein Modulator Antagonists / CGS 9343B

CGS 9343B

Catalog #: 2255
2 Citations Datasheet / COA / SDS
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2255/10
CGS 9343B | CAS No. 109826-27-9 | Calcium Binding Protein Modulator Antagonists
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Description: Calmodulin antagonist
Alternative Names: Zaldaride maleate

Chemical Name: 1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CGS 9343B is a calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.

Technical Data

M.Wt:
544.61
Formula:
C26H28N4O2.C4H4O4
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
109826-27-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CGS 9343B

The citations listed below are publications that use Tocris products. Selected citations for CGS 9343B include:

2 Citations: Showing 1 - 2

  1. The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
    Authors: Haag Et al.
    Cell Rep  2018;24:2418
  2. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
    Authors: Hou Et al.
    Eur J Immunol  2015;13:e1002233

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