CHPG Sodium salt

Catalog #: 3695
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3695/10
3695/50

CHPG Sodium salt | CAS No. 1303993-73-8 | Group I mGluR Agonists

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Description: Selective mGlu5 agonist; sodium salt of CHPG (Cat. No. 1049)

Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine sodium salt

Purity: ≥99%

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Product Details

Citations (2)

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Biological Activity

CHPG Sodium salt is a sodium salt of the selective mGlu₅ agonist CHPG (Cat. No. 1049).

Technical Data

M.Wt:

223.59

Formula:

C₈H₇ClNNaO₃

Solubility:

Soluble to 50 mM in water and to 50 mM in DMSO

Purity:

≥99%

Storage:

Store at RT

CAS No:

1303993-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

(RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu₅, but not mGlu₁, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Doherty et al.
Neuropharmacology, 1997;36:265
Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
Salt et al.
Br.J.Pharmacol., 1999;127:1057
Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia.
Bao et al.
Brain Res., 2001;922:173

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Citations for CHPG Sodium salt

The citations listed below are publications that use Tocris products. Selected citations for CHPG Sodium salt include:

2 Citations: Showing 1 - 2

Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells.
Authors: Hyuk Soo Et al.
Hepatology 2021;74:2170-2185
CHPG enhances BDNF and myelination in cuprizone-treated mice through astrocytic metabotropic glutamate receptor 5.
Authors: Yangyang Et al.
Glia 2021;69:1950-1965

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