Home / Acyl-CoA:Cholesterol Acyltransferase Inhibitors / CI 976

CI 976

Catalog #: 2227
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2227/10
2227/50
CI 976 | CAS No. 114289-47-3 | Acyl-CoA:Cholesterol Acyltransferase Inhibitors
1 Image
Description: Selective ACAT inhibitor

Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).

Technical Data

M.Wt:
393.57
Formula:
C23H39NO4
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
114289-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT.
    Krause et al.
    J.Lipid Res., 1993;34:279
  2. Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents.
    Sliskovic and White
    TiPS., 1991;12:194
  3. Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking.
    Drecktrah et al.
    Mol.Biol.Cell, 2003;14:3549

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CI 976

The citations listed below are publications that use Tocris products. Selected citations for CI 976 include:

2 Citations: Showing 1 - 2

  1. Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ
    Authors: Pagliuso Et al.
    Nature Communications  2016;7:12148
  2. Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function.
    Authors: Schmidt and Brown
    J Cell Biol  2009;186:211

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CI 976

There are currently no reviews for this product. Be the first to review CI 976 and earn rewards!

Have you used CI 976?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.