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CIM 0216

Catalog #: 5521
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5521/10
5521/50
CIM 0216 | CAS No. 1031496-06-6 | TRPM Agonists
1 Image
Description: Selective TRPM3 agonist

Chemical Name: 3,4-Dihydro-N-(5-methyl-3-isoxazolyl)-α-phenyl-1(2H)-quinolineacetamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CIM 0216 is a selective TRPM3 agonist. Exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. Stimulates insulin release from pancreatic islet cells in vitro. Evokes nocifensive behavior in mice.

Technical Data

M.Wt:
347.41
Formula:
C21H21N3O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1031496-06-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
    Held et al.
    Proc.Natl.Acad.Sci.U.S.A., 2015;112:E1363

Product Datasheets

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Citations for CIM 0216

The citations listed below are publications that use Tocris products. Selected citations for CIM 0216 include:

2 Citations: Showing 1 - 2

  1. ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.
    Authors: Xi Et al.
    Nat Commun  2021;12:1401
  2. Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels.
    Authors: Rubil and Thiel
    Channels (Austin)  2017;11:79

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