Home / Histamine H2 Receptor Antagonists / Cimetidine

Cimetidine

Catalog #: 0902
8 Citations Datasheet / COA / SDS
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0902/100
Cimetidine | CAS No. 51481-61-9 | Histamine H2 Receptor Antagonists
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Description: H2 antagonist, I1 agonist

Chemical Name: N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine

Purity: ≥99%

Product Details
Citations (8)
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Biological Activity

Cimetidine is a widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand.

Technical Data

M.Wt:
252.34
Formula:
C10H16N6S
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
51481-61-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Distribution, properties and functional characteristics of three classes of histamine receptor.
    Hill
    Pharmacol.Rev., 1990;42:45
  2. The imidazoline I1 receptor agonist, moxonidine, inhibits Ins secretion from isolated rat islets of langerhans.
    Tsoli et al.
    Eur.J.Pharmacol., 1995;284:199
  3. Inverse agonism of histamine H2 antagonists accounts for upregulation of spontaneously active receptors.
    Smit et al.
    Proc.Natl.Acad.Sci.U.S.A., 1996;93:6802
  4. A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors.
    Ernsberger et al.
    J.Cardiovasc.Pharmacol., 1992;20:S1

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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Citations for Cimetidine

The citations listed below are publications that use Tocris products. Selected citations for Cimetidine include:

8 Citations: Showing 1 - 8

  1. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
    Authors: Femenia Et al.
    Int J Neuropsychopharmacol  2015;18
  2. Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line.
    Authors: Wang Et al.
    J Neurosci  2014;3:1126
  3. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
    Authors: Kurtz Et al.
    Microcirculation  2014;21:593
  4. Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
    Authors: Francis Et al.
    Gut  2012;61:753
  5. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
    Authors: Connelly Et al.
    Br J Pharmacol  2009;157:55
  6. CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.
    Authors: Hough Et al.
    Neuropharmacology  2007;52:1244
  7. Enhancing functional production of G protein-coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen.
    Authors: André Et al.
    Protein Sci  2006;15:1115
  8. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.
    Authors: Strait Et al.
    J Clin Invest  2006;116:833

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