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cis-22a

Catalog #: 7118 Datasheet / COA / SDS
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7118/10
7118/50
cis-22a | CAS No. 1819366-84-1 | TRPV Inhibitors
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Description: TRPV6 inhibitor

Chemical Name: 1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine ditrifluoroacetate

Purity: ≥98%

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Biological Activity

cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Technical Data

M.Wt:
563.54
Formula:
C22H29N3.2CF3CO2H
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1819366-84-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Photoswitchable inhibitor of the calcium channel TRPV6.
    Cunha et al.
    ACS Med.Chem.Lett., 2019;10:1341
  2. Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method.
    Simonin et al.
    Angew.Chem.Int.Ed.Engl., 2015;54:14748

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