Clobenpropit dihydrobromide
Chemical Name: N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
Purity: ≥99%
Biological Activity
An extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303 -
Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor.
Buckland et al.
Br.J.Pharmacol., 2003;140:1117 -
Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow.
Liu et al.
Mol. Pharmacol., 2001;59:420 -
Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H3 receptor.
Van der Goot et al.
Eur.J.Med.Chem., 1992;27:511 -
Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.
Yokoyama et al.
Eur.J.Pharmacol., 1994;260:23
Product Datasheets
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Citations for Clobenpropit dihydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Clobenpropit dihydrobromide include:
4 Citations: Showing 1 - 4
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Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice.
Authors: Alkan Et al.
J Immunol 2015;2015:965056
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Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
Authors: Femenia Et al.
Int J Neuropsychopharmacol 2015;18
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Molecular pharmacology of human NMDA receptors.
Authors: Hedegaard Et al.
Neurochem Int 2012;61:601
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Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
Authors: Flamand Et al.
Br J Pharmacol 2004;141:552
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