Home / KCC2 Activators / CLP 257

CLP 257

Catalog #: 5242
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5242/50
5242/10
CLP 257 | CAS No. 1181081-71-9 | KCC2 Activators
1 Image
Description: Selective KCC2 activator

Chemical Name: (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CLP 257 is a selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.

Technical Data

M.Wt:
307.34
Formula:
C14H14FN3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1181081-71-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Chloride extrusion enhancers as novel therapeutics for neurological diseases.
    Gagnon et al.
    Nat.Med., 2013;19:1524

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for CLP 257

The citations listed below are publications that use Tocris products. Selected citations for CLP 257 include:

1 Citation: Showing 1 - 1

  1. Diminished KCC2 confounds synapse specificity of LTP during senescence.
    Authors: Ferando Et al.
    Nat Neurosci  2016;19:1197

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CLP 257

There are currently no reviews for this product. Be the first to review CLP 257 and earn rewards!

Have you used CLP 257?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.