CMA
Chemical Name: 9-Oxo-10(9H)-acridineacetic acid
Purity: ≥98%
Biological Activity
CMA is a STING agonist; murine-selective (Kd = 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Rat and human STINGs profile similarly towards anticancer/antiviral compounds.
Zhang et al.
Sci. Rep., 2015;5:18035 -
Targeting STING with covalent small-molecule inhibitors.
Haag et al.
Nature, 2018;559:269 -
Species-specific detection of the antiviral small-molecule compound CMA by STING.
Cavlar et al.
EMBO J., 2013;32:1440
Product Datasheets
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Citation for CMA
The citations listed below are publications that use Tocris products. Selected citations for CMA include:
1 Citation: Showing 1 - 1
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Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.
Authors: Jie Et al.
iScience 2023;26:106758
FAQs
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