COG 133

Catalog #: 3405
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3405/1

1 Image

Description: ApoE peptide fragment

Alternative Names: apoE(133-149)

Purity: ≥95%

View All Products for LDL Receptor Peptides

Product Details

Citations (1)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

COG 133 is an apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC₅₀ = 445 nM).

Technical Data

M.Wt:

2169.73

Formula:

C₉₇H₁₈₁N₃₇O₁₉

Sequence:

LRVRLASHLRKLRKRLL

(Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

514200-66-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Apolipoprotein E-derived peptides block α7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
Gay et al.
J.Pharmacol.Exp.Ther., 2006;316:835
Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.
Li et al.
J.Pharmacol.Exp.Ther., 2006;318:956
N-MthD.-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.
Sheng et al.
Neuropharmacology, 2008;55:204

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for COG 133

The citations listed below are publications that use Tocris products. Selected citations for COG 133 include:

1 Citation: Showing 1 - 1

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.
Authors: Tavazoie Et al.
Cell 2018;172:825

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for COG 133

There are currently no reviews for this product. Be the first to review COG 133 and earn rewards!

Have you used COG 133?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.