CometAssay Single Cell Gel Electrophoresis Assay

Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIalpha catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells
Authors: KH Jeon, S Park, JH Shin, AR Jung, SY Hwang, SH Seo, H Jo, Y Na, Y Kwon
European Journal of Medicinal Chemistry, 2022-12-05;246(0):114999.  2022-12-05

Wip1 contributes to the adaptation of HepG2 human liver cancer cells to stress hormone-induced DNA damage
Authors: G Li, Y Qian, Y Chen, M Cao, X Yang, D Kong, G Wang, H An, N Yang, W Huang, Y Liu
Oncology Letters, 2022-11-29;25(1):31.  2022-11-29

TGFbeta pathway is required for viable gestation of Fanconi anemia embryos
Authors: A Rodríguez, M Epperly, J Filiatraul, M Velázquez, C Yang, K McQueen, LA Sambel, H Nguyen, DR Iyer, U Juárez, C Ayala-Zamb, DB Martignett, S Frías, R Fisher, K Parmar, JS Greenberge, AD D'Andrea
PloS Genetics, 2022-11-28;18(11):e1010459.  2022-11-28

Construction of an In Vitro Air-Liquid Interface Exposure System to Assess the Toxicological Impact of Gas and Particle Phase of Semi-Volatile Organic Compounds
Authors: S Binder, N Rastak, E Karg, A Huber, E Kuhn, GC Dragan, C Monsé, D Breuer, S Di Bucchia, MN Delaval, S Oeder, M Sklorz, R Zimmermann
Toxics, 2022-11-26;10(12):.  2022-11-26

Ginsenoside Rh2 sensitizes the anti-cancer effects of sunitinib by inducing cell cycle arrest in renal cell carcinoma
Authors: HJ Hwang, SH Hong, HS Moon, YE Yoon, SY Park
Scientific Reports, 2022-11-17;12(1):19752.  2022-11-17

FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition
Authors: S Li, J Deng, D Sun, S Chen, X Yao, N Wang, J Zhang, Q Gu, S Zhang, J Wang, S Zhu, H Zhu, H Li, X Xu, F Wei
Redox Biology, 2022-11-15;58(0):102530.  2022-11-15

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
Authors: JA Oo, K Pálfi, T Warwick, I Wittig, C Prieto-Gar, V Matkovic, I Tomaškovi?, F Boos, J Izquierdo, T Teichmann, K Petriukov, S Haydar, L Maegdefess, Z Wu, MD Pham, J Krishnan, AH Baker, S Günther, HD Ulrich, I Dikic, MS Leisegang, RP Brandes
Cell Reports, 2022-11-15;41(7):111670.  2022-11-15

PARP1 proximity proteomics reveals interaction partners at stressed replication forks
Authors: T Mosler, HI Baymaz, JF Gräf, I Mikicic, G Blattner, E Bartlett, M Ostermaier, R Piccinno, J Yang, A Voigt, M Gatti, S Pellegrino, M Altmeyer, K Luck, I Ahel, V Roukos, P Beli
Nucleic Acids Research, 2022-11-11;0(0):.  2022-11-11

NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
Authors: N Li, Y Xu, H Chen, L Chen, Y Zhang, T Yu, R Yao, J Chen, Q Fu, J Zhou, J Wang
Cell Reports, 2022-11-08;41(6):111600.  2022-11-08

Revealing microcystin-LR ecotoxicity to earthworm (Eisenia fetida) at the intestinal cell level
Authors: X Liu, JC Ye, F Li, RJ Gao, XX Wang, JL Cheng, BL Liu, L Xiang, YW Li, QY Cai, HM Zhao, CH Mo, QX Li
Chemosphere, 2022-10-29;311(0):137046.  2022-10-29

Discovery and Validation of Potential Serum Biomarkers with Pro-Inflammatory and DNA Damage Activities in Ulcerative Colitis: A Comprehensive Untargeted Metabolomic Study
Authors: M Li, R Zhang, M Xin, Y Xu, S Liu, B Yu, B Zhang, J Liu
Metabolites, 2022-10-20;12(10):.  2022-10-20

MED1, a novel binding partner of BRCA1, regulates homologous recombination and R-loop processing
Authors: H Honjoh, M Tanikawa, O Wada-Hirai, K Oda, H Inaba, A Kukita, Y Kawata, M Kusakabe, S Tsuchimoch, A Taguchi, Y Miyamoto, K Sone, T Tsuruga, M Mori-Uchin, Y Matsumoto, Y Osuga
Scientific Reports, 2022-10-13;12(1):17140.  2022-10-13

Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival
Authors: V Vijayakuru, K Maeng, HS Lee, BS Meyer, S Burkett, A Nawab, MW Dougherty, C Jobin, I Mahmud, TJ Garrett, M Feely, KB Lee, FJ Kaye, MV Guijarro, M Zajac-Kaye
JCI Insight, 2022-10-10;0(0):.  2022-10-10

A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme
Authors: F Wei, CJ Neal, TS Sakthivel, Y Fu, M Omer, A Adhikary, S Ward, KM Ta, S Moxon, M Molinari, J Asiatico, M Kinzel, SN Yarmolenko, V San Cheong, N Orlovskaya, R Ghosh, S Seal, M Coathup
Bioactive materials, 2022-09-21;21(0):547-565.  2022-09-21

Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
Authors: A Ulsamer, A Martínez-L, S Bader, S Rodríguez-, R Freire, J Méndez, E de Nadal, F Posas
Cell Reports, 2022-09-20;40(12):111375.  2022-09-20

Impacts of arsenic on Rad18 and translesion synthesis
Authors: LB Volk, KL Cooper, T Jiang, ML Paffett, LG Hudson
Toxicology and Applied Pharmacology, 2022-09-08;454(0):116230.  2022-09-08

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots
Authors: S Yuan, T Huang, Z Bao, S Wang, X Wu, J Liu, H Liu, ZJ Chen
Genome Biology, 2022-09-06;23(1):187.  2022-09-06

LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms
Authors: R Yu, Y Hu, S Zhang, X Li, M Tang, M Yang, X Wu, Z Li, X Liao, Y Xu, M Li, S Chen, W Qian, LY Gong, L Song, J Li
Nucleic Acids Research, 2022-08-12;0(0):.  2022-08-12

PAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer
Authors: W Huang, Z Han, Z Sun, H Feng, L Zhao, Q Yuan, C Chen, S Yu, Y Hu, J Yu, H Liu, G Li, Y Jiang
Cell Death & Disease, 2022-07-28;13(7):658.  2022-07-28

Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS
Authors: E Gusho, LA Laimins
PloS Pathogens, 2022-07-25;18(7):e1010725.  2022-07-25

Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD+ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase
Authors: J Li, CA Koczor, KM Saville, F Hayat, A Beiser, S McClellan, ME Migaud, RW Sobol
Cancers, 2022-07-22;14(15):.  2022-07-22

TDP1-independent pathways in the process and repair of TOP1-induced DNA damage
Authors: H Zhang, Y Xiong, D Su, C Wang, M Srivastava, M Tang, X Feng, M Huang, Z Chen, J Chen
Nature Communications, 2022-07-22;13(1):4240.  2022-07-22

Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast
Authors: S Zhao, Y Hong, YY Liang, XL Li, JC Shen, CC Sun, LL Chu, J Hu, H Wang, DX Xu, SC Zhang, DD Xu, T Xu, LL Zhao
Redox Biology, 2022-07-20;55(0):102414.  2022-07-20

DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1
Authors: WL Lin, JK Chen, X Wen, W He, GA Zarceno, Y Chen, S Chen, TT Paull, HW Liu
Cell Reports, 2022-07-19;40(3):111089.  2022-07-19

Healthy cloned offspring derived from freeze-dried somatic cells
Authors: S Wakayama, D Ito, E Hayashi, T Ishiuchi, T Wakayama
Nature Communications, 2022-07-05;13(1):3666.  2022-07-05

Effective Radiosensitization of Bladder Cancer Cells by Pharmacological Inhibition of DNA-PK and ATR
Authors: AA Chughtai, J Pannhausen, P Dinger, J Wirtz, R Knüchel, NT Gaisa, MJ Eble, M Rose
Biomedicines, 2022-05-30;10(6):.  2022-05-30

RNase H2, mutated in Aicardi-Gouti�res syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
Authors: A Cristini, M Tellier, F Constantin, C Accalai, LO Albulescu, R Heiringhof, N Bery, O Sordet, S Murphy, N Gromak
Nature Communications, 2022-05-26;13(1):2961.  2022-05-26

Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIalpha intron-19 5' splice site: Generation of etoposide resistance in human leukemia K562 cells
Authors: VA Hernandez, J Carvajal-M, X Wang, M Pietrzak, JC Yalowich, TS Elton
PLoS ONE, 2022-05-26;17(5):e0265794.  2022-05-26

Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer
Authors: M Stanzione, J Zhong, E Wong, TJ LaSalle, JF Wise, A Simoneau, DT Myers, S Phat, M Sade-Feldm, MS Lawrence, MK Hadden, L Zou, AF Farago, NJ Dyson, BJ Drapkin
Science Advances, 2022-05-13;8(19):eabn1229.  2022-05-13

Hesperadin suppresses pancreatic cancer through ATF4/GADD45A axis at nanomolar concentrations
Authors: Y Zhang, J Wu, Y Fu, R Yu, H Su, Q Zheng, H Wu, S Zhou, K Wang, J Zhao, S Shen, G Xu, L Wang, C Yan, X Zou, Y Lv, S Zhang
Oncogene, 2022-05-12;0(0):.  2022-05-12

Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response
Authors: Q Ke, L Gong, X Zhu, R Qi, M Zou, B Chen, W Liu, S Huang, Y Liu, DW Li
Cells, 2022-05-05;11(9):.  2022-05-05

Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes
Authors: AN Nail, LM McCaffrey, M Banerjee, AP Ferragut C, JC States
Toxicology and Applied Pharmacology, 2022-05-02;446(0):116042.  2022-05-02

Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming-A New Mechanism for SCLC Chemoresistance Boosted by Nicotine
Authors: Y Wang, T Bian, L Song, Y Jiang, Z Huo, RG Salloum, GW Warren, FJ Kaye, N Fujioka, L Jin, C Xing
Cancers, 2022-05-02;14(9):.  2022-05-02

Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism
Authors: TM Jones, CM Espitia, A Ooi, JE Bauman, JS Carew, ST Nawrocki
Cell Death & Disease, 2022-04-15;13(4):350.  2022-04-15

The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1
Authors: I Hirschler-, F Festa, S Huang, GL Moldovan, C Nicolae, A Dhoonmoon, L Bao, K Keefer, SJ Chen, HG Wang, JY Cheung, BA Miller
Scientific Reports, 2022-04-15;12(1):6311.  2022-04-15

Cytotoxicity, crosslinking and biological activity of three mitomycins
Authors: SY Cheng, L Delgado-Cr, CC Clement, O Zacarias, M Concheiro-, N Towler, T Snyder, M Zheng, N Almodovar, C Gonzalez, M Romaine, AM Sapse, E Champeil
Bioorganic chemistry, 2022-03-22;123(0):105744.  2022-03-22

Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
Authors: A Reilly, J Philip Cre, S Stewart, MC Stolla, Y Wang, J Du, R Wellington, S Busch, EH Estey, PS Becker, M Fang, SB Keel, JL Abkowitz, LA Soma, J Ma, Z Duan, S Doulatov
Cell Stem Cell, 2022-03-11;0(0):.  2022-03-11

Assessment of the ameliorative effect of curcumin on pendimethalin-induced genetic and biochemical toxicity
Authors: A Acar, D Singh, AK Srivastava
Scientific Reports, 2022-02-09;12(1):2195.  2022-02-09

SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia
Authors: C Han, A Khodadadi-, AH Lorch, Q Jin, V Serafin, P Zhu, Y Politanska, L Sun, BT Gutierrez-, MV Pryzhkova, H Abdala-Val, ET Bartom, B Buldini, G Basso, SE Velu, K Sarma, BB Mattamana, BK Cho, RC Obeng, YA Goo, PW Jordan, A Tsirigos, Y Zhou, P Ntziachris
Science Advances, 2022-01-21;8(3):eabj8357.  2022-01-21

VDAC1 oligomerization may enhance DDP-induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage
Authors: X Zhu, L Luo, Y Xiong, N Jiang, Y Wang, Y Lv, Y Xie
FEBS Open Bio, 2022-01-14;0(0):.  2022-01-14

The Salutary Effects of Catalpol on Diesel Exhaust Particles-Induced Thrombogenic Changes and Cardiac Oxidative Stress, Inflammation and Apoptosis
Authors: A Nemmar, S Beegam, NE Zaaba, S Alblooshi, S Alseiari, BH Ali
Biomedicines, 2022-01-04;10(1):.  2022-01-04

Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion
Authors: M Tolouee, KDW Hendriks, FF Lie, LP Gartzke, M Goris, F Hoogstra-B, S Bergink, RH Henning
Cell Transplantation, 2022-01-01;31(0):9636897221108.  2022-01-01

Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage
Authors: P Carotenuto, F Amato, A Lampis, C Rae, S Hedayat, MC Previdi, D Zito, M Raj, V Guzzardo, F Sclafani, A Lanese, C Parisi, C Vicentini, I Said-Hunti, JC Hahne, A Hallsworth, V Kirkin, K Young, R Begum, A Wotherspoo, K Kouvelakis, SX Azevedo, V Michalarea, R Upstill-Go, S Rao, D Watkins, N Starling, A Sadanandam, DK Chang, AV Biankin, NB Jamieson, A Scarpa, D Cunningham, I Chau, P Workman, M Fassan, N Valeri, C Braconi
Nature Communications, 2021-11-18;12(1):6738.  2021-11-18

Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3 signaling
Authors: S Hu, S Ren, Y Cai, J Liu, Y Han, Y Zhao, J Yang, X Zhou, X Wang
Cell Death and Differentiation, 2021-11-06;0(0):.  2021-11-06

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
Authors: F Napoletano, G Ferrari Br, IAP Voto, A Santin, L Celora, E Campaner, C Dezi, A Bertossi, E Valentino, M Santorsola, A Rustighi, V Fajner, E Maspero, F Ansaloni, V Cancila, CF Valenti, M Santo, OB Artimagnel, S Finaurini, U Gioia, S Polo, R Sanges, C Tripodo, A Mallamaci, S Gustincich, F d'Adda di, F Mantovani, V Specchia, G Del Sal
Cell Reports, 2021-09-14;36(11):109694.  2021-09-14

Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia
Authors: J Bloehdorn, A Braun, A Taylor-Wei, BMC Jebaraj, S Robrecht, J Krzykalla, H Pan, A Giza, G Akylzhanov, K Holzmann, A Scheffold, HE Johnston, RF Yeh, T Klymenko, E Tausch, B Eichhorst, L Bullinger, K Fischer, M Weisser, T Robak, C Schneider, J Gribben, LN Dahal, MJ Carter, O Elemento, DA Landau, DS Neuberg, MS Cragg, A Benner, M Hallek, CJ Wu, H Döhner, S Stilgenbau, D Mertens
Nature Communications, 2021-09-13;12(1):5395.  2021-09-13

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
Authors: Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier
Nature Communications, 2021-08-18;12(1):5010.  2021-08-18

Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling
Authors: S Pal, BR Nixon, MS Glennon, P Shridhar, SL Satterfiel, YR Su, JR Becker
Journal of the American Heart Association, 2021-07-29;10(15):e021768.  2021-07-29

Antifungal agent Terbinafine restrains tumor growth in preclinical models of hepatocellular carcinoma via AMPK-mTOR axis
Authors: EB Zhang, X Zhang, K Wang, F Zhang, TW Chen, N Ma, QZ Ni, YK Wang, QW Zheng, HJ Cao, J Xia, B Zhu, S Xu, X Ding, X Wang, Z Li, S Cheng, D Xie, JJ Li
Oncogene, 2021-07-10;0(0):.  2021-07-10

Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
Authors: MM Lou, XQ Tang, GM Wang, J He, F Luo, MF Guan, F Wang, H Zou, JY Wang, Q Zhang, MJ Xu, QL Shi, LB Shen, GM Ma, Y Wu, YY Zhang, AB Liang, TH Wang, LL Xiong, J Wang, J Xu, WY Wang
Nature Communications, 2021-07-01;12(1):4075.  2021-07-01

Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
Authors: JH Park, SJ Ryu, BJ Kim, HJ Cho, CH Park, HJC Choi, EJ Jang, EJ Yang, JA Hwang, SH Woo, JH Lee, JH Park, KM Choi, YY Kwon, CK Lee, JT Park, SC Cho, YI Lee, SB Lee, JA Han, KA Cho, MS Kim, D Hwang, YS Lee, SC Park
Experimental & Molecular Medicine, 2021-06-29;53(6):1092-1108.  2021-06-29

Combination of chemotherapy with BRAF inhibitors results in effective eradication of malignant melanoma by preventing ATM-dependent DNA repair
Authors: J Alonso-Mar, A Villanueva, JM Piulats, M Martínez-I, L Solé, J Martín-Lib, S Segura, RM Pujol, M Iglesias, A Bigas, F Gallardo, L Espinosa
Oncogene, 2021-06-17;0(0):.  2021-06-17

PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA
Authors: K Yano, RU Takahashi, B Shiotani, J Abe, T Shidooka, Y Sudo, Y Yamamoto, S Kan, H Sakagami, H Tahara
The Journal of Biological Chemistry, 2021-06-16;297(1):100882.  2021-06-16

Exosome-derived microRNA-433 inhibits tumorigenesis through incremental infiltration of CD4 and CD8 cells in non-small cell lung cancer
Authors: B Liu, R Zhang, Y Zhu, R Hao
Oncology Letters, 2021-06-15;22(2):607.  2021-06-15

Targeting lactate dehydrogenase a improves radiotherapy efficacy in non-small cell lung cancer: from bedside to bench
Authors: Y Yang, Y Chong, M Chen, W Dai, X Zhou, Y Ji, G Qiu, X Du
Journal of Translational Medicine, 2021-04-26;19(1):170.  2021-04-26

Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling
Authors: C Yang, C Tian, TE Hoffman, NK Jacobsen, SL Spencer
Nature Communications, 2021-03-19;12(1):1747.  2021-03-19

WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer
Authors: Q Zhou, X Chen, H He, S Peng, Y Zhang, J Zhang, L Cheng, S Liu, M Huang, R Xie, T Lin, J Huang
Theranostics, 2021-03-04;11(10):4809-4824.  2021-03-04

AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
Authors: Y Jiang, Y Dong, Y Luo, S Jiang, FL Meng, M Tan, J Li, Y Zang
Cell Reports, 2021-02-16;34(7):108713.  2021-02-16

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells
Authors: A Iftekhar, H Berger, N Bouznad, J Heuberger, F Boccellato, U Dobrindt, H Hermeking, M Sigal, TF Meyer
Nature Communications, 2021-02-12;12(1):1003.  2021-02-12

USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-&beta2 transcription
Authors: X Jie, WP Fong, R Zhou, Y Zhao, Y Zhao, R Meng, S Zhang, X Dong, T Zhang, K Yang, G Wu, S Xu
Cell Death and Differentiation, 2021-02-08;0(0):.  2021-02-08

Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells
Authors: W Zhang, J Yang, Y Chen, R Xue, Z Mao, W Lu, Y Jiang
Aging Cell, 2021-01-17;0(0):e13307.  2021-01-17

Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer
Authors: S Lim, Y Kim, SB Lee, HG Kang, DH Kim, JW Park, D Chung, H Kong, KH Yoo, Y Kim, W Han, KH Chun, JH Park
Oncogenesis, 2020-10-11;9(10):91.  2020-10-11

Mahogunin Ring Finger 1 Is Required for Genomic Stability and Modulates the Malignant Phenotype of Melanoma Cells
Authors: I Martínez-V, M Abrisqueta, C Herraiz, J Sirés-Camp, M Castejón-G, DC Bennett, C Olivares, JC García-Bor, C Jiménez-Ce
Cancers (Basel), 2020-10-01;12(10):.  2020-10-01

MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
Authors: A Rodríguez, K Zhang, A Färkkilä, J Filiatraul, C Yang, M Velázquez, E Furutani, DC Goldman, B García de, G Garza-Mayé, K McQueen, LA Sambel, B Molina, L Torres, M González, E Vadillo, R Pelayo, WH Fleming, M Grompe, A Shimamura, S Hautaniemi, J Greenberge, S Frías, K Parmar, AD D'Andrea
Cell Stem Cell, 2020-09-29;0(0):.  2020-09-29

Antiplasmodial and Genotoxic Study of Selected Ghanaian Medicinal Plants
Authors: S Adukpo, D Elewosi, RH Asmah, AK Nyarko, PK Ekpe, DA Edoh, MF Ofori
Evid Based Complement Alternat Med, 2020-09-23;2020(0):1582724.  2020-09-23

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
Authors: DS Edwards, R Maganti, JP Tanksley, J Luo, JJH Park, E Balkanska-, J Ling, SR Floyd
Cell Rep, 2020-09-22;32(12):108166.  2020-09-22

Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
Authors: A Chakrabort, P Jenjaroenp, J Li, S El Hilali, A McCulley, B Haarer, EA Hoffman, A Belak, A Thorland, H Hehnly, C Schildkrau, CL Chen, VA Kuznetsov, W Feng
Cell Rep, 2020-09-22;32(12):108179.  2020-09-22

Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents
Authors: M Deng, J Lin, S Nowsheen, T Liu, Y Zhao, PW Villalta, D Sicard, DJ Tschumperl, S Lee, J Kim, Z Lou
Science Advances, 2020-09-11;6(37):.  2020-09-11

UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance
Authors: Y Huang, X Yang, Y Lu, Y Zhao, R Meng, S Zhang, X Dong, S Xu, G Wu
Cell Death Differ., 2020-09-08;0(0):.  2020-09-08

Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
Authors: SE Noh, YS Juhnn
Sci Rep, 2020-09-02;10(1):14455.  2020-09-02

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
Authors: S Sengupta, H Wang, C Yang, B Szczesny, ML Hegde, S Mitra
Proc. Natl. Acad. Sci. U.S.A., 2020-08-21;0(0):.  2020-08-21

BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage
Authors: FC Lam, YW Kong, Q Huang, TL Vu Han, AD Maffa, EM Kasper, MB Yaffe
Nat Commun, 2020-08-14;11(1):4083.  2020-08-14

Signaling from Plastid Genome Stability Modulates Endoreplication and Cell Cycle during Plant Development
Authors: S Duan, L Hu, B Dong, HL Jin, HB Wang
Cell Rep, 2020-08-11;32(6):108019.  2020-08-11

Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway
Authors: Y Wang, S Chen, S Sun, G Liu, L Chen, Y Xia, J Cui, W Wang, X Jiang, L Zhang, Y Zhu, Y Zou, B Shi
Front Pharmacol, 2020-07-24;11(0):1152.  2020-07-24

13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity Against Oral Cancer Cells Through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts
Authors: YC Liu, BR Peng, KC Hsu, M El-Shazly, SP Shih, TE Lin, FW Kuo, YC Chou, HY Lin, MC Lu
Mar Drugs, 2020-07-23;18(8):.  2020-07-23

An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging
Authors: L Gao, Y Zhang, L Zhao, W Niu, Y Tang, F Gao, P Cai, Q Yuan, X Wang, H Jiang, X Gao
Sci Adv, 2020-07-15;6(29):eabb1421.  2020-07-15

Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer
Authors: DH Ha, A Min, S Kim, H Jang, SH Kim, HJ Kim, HS Ryu, JL Ku, KH Lee, SA Im
Sci Rep, 2020-06-18;10(1):9930.  2020-06-18

Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
Authors: C Zhu, A Rogers, K Asleh, J Won, D Gao, S Leung, S Li, KR Vij, J Zhu, JM Held, Z You, TO Nielsen, J Shao
Cell Rep, 2020-06-09;31(10):107745.  2020-06-09

HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies
Authors: CC Wu, LW Jin, IF Wang, WY Wei, PC Ho, YC Liu, KJ Tsai
EMBO Mol Med, 2020-05-25;12(6):e10622.  2020-05-25

Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function
Authors: Q Lin, L Wu, Z Ma, FA Chowdhury, HH Mazumder, W Du
JCI Insight, 2020-05-21;5(10):.  2020-05-21

Inhibition of HIF-1alpha by Atorvastatin During 131I-RTX Therapy in Burkitt's Lymphoma Model
Authors: EH Kim, HY Ko, AR Yu, H Kim, J Zaheer, HJ Kang, YC Lim, KD Cho, HY Joo, MK Kang, JJ Lee, SS Lee, HJ Kang, SM Lim, JS Kim
Cancers (Basel), 2020-05-11;12(5):.  2020-05-11

Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
Authors: S Ohba, TA Johannesse, K Chatla, X Yang, RO Pieper, J Mukherjee
Cell Rep, 2020-04-14;31(2):107518.  2020-04-14

Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair
Authors: N Li, J Wang, SS Wallace, J Chen, J Zhou, AD D'Andrea
Nucleic Acids Res., 2020-04-06;0(0):.  2020-04-06

Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
Authors: Y Shen, W Ha, W Zeng, D Queen, L Liu
Sci Rep, 2020-03-18;10(1):4943.  2020-03-18

Fitter Mitochondria Are Associated With Radioresistance in Human Head and Neck SQD9 Cancer Cells
Authors: D Grasso, HCD Medeiros, LX Zampieri, V Bol, P Danhier, MW van Gisber, C Bouzin, D Brusa, V Grégoire, H Smeets, APM Stassen, LJ Dubois, P Lambin, M Dutreix, P Sonveaux
Front Pharmacol, 2020-03-13;11(0):263.  2020-03-13

Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15
Authors: E Kong, HD Kim, J Kim
Cell Death Differ., 2020-03-03;0(0):.  2020-03-03

Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells
Authors: E Nigro, G Crescente, M Formato, MT Pecoraro, M Mallardo, S Piccolella, A Daniele, S Pacifico
Molecules, 2020-02-26;25(5):.  2020-02-26

ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma
Authors: B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha, Q Ye, C Jiang, J Cai, T Jiang
Theranostics, 2020-02-10;10(7):3351-3365.  2020-02-10

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors
Authors: JR Delaney, CB Patel, J Bapat, CM Jones, M Ramos-Zapa, KK Ortell, R Tanios, M Haghighiab, J Axelrod, JW DeStefano, I Tancioni, DD Schlaepfer, O Harismendy, AR La Spada, DG Stupack
PLoS Genet., 2020-01-10;16(1):e1008558.  2020-01-10

Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers
Authors: JF Putri, P Bhargava, JK Dhanjal, T Yaguchi, D Sundar, SC Kaul, R Wadhwa
J. Exp. Clin. Cancer Res., 2019-12-19;38(1):499.  2019-12-19

ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
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Nat Commun, 2019-12-16;10(1):5718.  2019-12-16

Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
Authors: E Khattar, KZY Maung, CL Chew, A Ghosh, MMH Mok, P Lee, J Zhang, WHJ Chor, G Cildir, CQ Wang, NK Mohd-Ismai, DWL Chin, SC Lee, H Yang, YJ Shin, DH Nam, L Chen, AP Kumar, LW Deng, M Ikawa, J Gunaratne, M Osato, V Tergaonkar
Nat Commun, 2019-12-13;10(1):5349.  2019-12-13

E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes
Authors: T Muthumalag, T Lamb, MR Friedman, I Rahman
Sci Rep, 2019-12-13;9(1):19035.  2019-12-13

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
Authors: D Andrade, M Mehta, J Griffith, S Oh, J Corbin, A Babu, S De, A Chen, YD Zhao, S Husain, S Roy, L Xu, J Aube, R Janknecht, M Gorospe, T Herman, R Ramesh, A Munshi
Cancers (Basel), 2019-12-13;11(12):.  2019-12-13

Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse
Authors: G Urrutia, A Salmonson, JA Toro-Zapat, TM de Assunca, A Mathison, N Dusetti, J Iovanna, R Urrutia, G Lomberk
Mol. Cancer Res., 2019-12-10;0(0):.  2019-12-10

Combined cell death of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells: Molecular insights into the joint action
Authors: S Zhang, J Zhang, W Cheng, H Chen, A Wang, Y Liu, H Hou, Q Hu
Chemosphere, 2019-11-29;244(0):125482.  2019-11-29

IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage
Authors: J Panneersel, A Srivastava, M Mehta, A Chen, YD Zhao, A Munshi, R Ramesh
Cancers (Basel), 2019-11-27;11(12):.  2019-11-27

APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells
Authors: CD Stefanski, K Keffler, S McClintock, L Milac, JR Prosperi
Neoplasia, 2019-11-20;21(12):1143-1150.  2019-11-20

Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
Authors: M Hong, J Li, S Li, M M Almutair
Cells, 2019-11-19;8(11):.  2019-11-19

Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
Authors: DS Metselaar, MH Meel, B Benedict, P Waranecki, J Koster, GJL Kaspers, E Hulleman
EBioMedicine, 2019-11-14;0(0):.  2019-11-14

Cisplatin exposure causes c-Myc-dependent resistance to CDK4/6 inhibition in HPV-negative head and neck squamous cell carcinoma
Authors: AM Robinson, R Rathore, NJ Redlich, DR Adkins, T VanArsdale, BA Van Tine, LS Michel
Cell Death Dis, 2019-11-14;10(11):867.  2019-11-14

Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response
Authors: J Dziegielew, MA Bo?kowska, EA Poniecka, J Heo, K Du, RB Crittenden, TP Bender, DL Brautigan, JM Larner
DNA Repair (Amst.), 2019-11-09;85(0):102737.  2019-11-09

Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation
Authors: Y Yu, W Jia, Y Lyu, D Su, M Bai, J Shen, J Qiao, T Han, W Liu, J Chen, W Chen, D Ye, X Guo, S Zhu, J Xi, R Zhu, X Wan, S Gao, J Zhu, J Kang
Cell Discov, 2019-11-05;5(0):47.  2019-11-05

BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells
Authors: TY Lin, HH Chan, SH Chen, S Sarvagalla, PS Chen, MS Coumar, SM Cheng, YC Chang, CH Lin, E Leung, CHA Cheung
Autophagy, 2019-10-15;0(0):1-18.  2019-10-15

Precision Chemo-Radiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability
Authors: DV Hingorani, MK Doan, MF Camargo, J Aguilera, SM Song, D Pizzo, DJ Scanderbeg, EEW Cohen, AM Lowy, SR Adams, SJ Advani
Mol. Cancer Ther., 2019-10-09;0(0):.  2019-10-09

Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia
Authors: SEF Kost, A Saleh, EM Mejia, M Mostafizar, EDJ Bouchard, V Banerji, AJ Marshall, SB Gibson, JB Johnston, S Katyal
Cancers (Basel), 2019-10-09;11(10):.  2019-10-09

Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)
Authors: AL Perl, CM O'Connor, P Fa, F Mayca Pozo, J Zhang, Y Zhang, G Narla
J. Biol. Chem., 2019-09-27;0(0):.  2019-09-27

Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
Authors: S Giovannini, MC Weller, S Repmann, H Moch, J Jiricny
Nucleic Acids Res., 2019-09-26;0(0):.  2019-09-26

Male mice, caged in the International Space Station for 35 days, sire healthy offspring
Authors: T Matsumura, T Noda, M Muratani, R Okada, M Yamane, A Isotani, T Kudo, S Takahashi, M Ikawa
Sci Rep, 2019-09-24;9(1):13733.  2019-09-24

TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
Authors: J Chen, Z Wang, X Guo, F Li, Q Wei, X Chen, D Gong, Y Xu, W Chen, Y Liu, J Kang, Y Shi
Nat Commun, 2019-09-19;10(1):4273.  2019-09-19

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts
Authors: EY Chang, S Tsai, MJ Aristizaba, JP Wells, Y Coulombe, FF Busatto, YA Chan, A Kumar, Y Dan Zhu, AY Wang, LA Fournier, P Hieter, MS Kobor, JY Masson, PC Stirling
Nat Commun, 2019-09-19;10(1):4265.  2019-09-19

Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage
Authors: Y Zhou, Y Xu, L Lu, J Ni, J Nie, J Cao, Y Jiao, Q Zhang
Theranostics, 2019-09-18;9(22):6665-6675.  2019-09-18

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
Authors: A Cristini, G Ricci, S Britton, S Salimbeni, SN Huang, J Marinello, P Calsou, Y Pommier, G Favre, G Capranico, N Gromak, O Sordet
Cell Rep, 2019-09-17;28(12):3167-3181.e6.  2019-09-17

The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas
Authors: F Valenti, A Sacconi, F Ganci, G Grasso, S Strano, G Blandino, S Di Agostin
Cancers (Basel), 2019-09-11;11(9):.  2019-09-11

Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response
Authors: S Lin, L Yu, X Song, J Bi, L Jiang, Y Wang, M He, Q Xiao, M Sun, OI Olopade, L Zhao, M Wei
Cell Death Dis, 2019-09-11;10(9):666.  2019-09-11

Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells
Authors: C Mani, S Jonnalagad, J Lingareddy, S Awasthi, WH Gmeiner, K Palle
Breast Cancer Res., 2019-09-06;21(1):104.  2019-09-06

LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
Authors: JP Cebrià-Cos, L Pascual-Re, A Gonzalez-P, G Serra-Bard, J Querol, M Cosín, G Verde, RA Cigliano, W Sanseverin, S Segura-Bay, A Iturbide, D Andreu, P Nuciforo, C Bernado-Mo, V Rodilla, J Arribas, J Yelamos, AG de Herrero, TH Stracker, S Peiró
Oncogene, 2019-08-28;0(0):.  2019-08-28

Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells
Authors: A Kopacz, D Klóska, B Proniewski, D Cysewski, N Personnic, A Piechota-P, P Kaczara, A Zakrzewska, HJ Forman, J Dulak, A Józkowicz, A Grochot-Pr
Redox Biol, 2019-08-22;28(0):101304.  2019-08-22

Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)
Authors: P Nagarajan, PA Agudelo Ga, CC Iyer, LV Popova, WD Arnold, MR Parthun
Aging Cell, 2019-07-10;0(0):e12992.  2019-07-10

A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells
Authors: J Jiang, N Mao, H Hu, J Tang, D Han, S Liu, Q Wu, Y Liu, C Peng, J Lai, C Yang
Proc. Natl. Acad. Sci. U.S.A., 2019-07-08;0(0):.  2019-07-08

Selective Killing of RAS-Malignant Tissues by Exploiting Oncogene-Induced DNA Damage
Authors: L Murcia, M Clemente-R, P Pierre-Eli, A Royou, M Milán
Cell Rep, 2019-07-02;28(1):119-131.e4.  2019-07-02

miR-200c Modulates the Pathogenesis of Radiation-Induced Oral Mucositis
Authors: J Tao, M Fan, D Zhou, Y Hong, J Zhang, H Liu, S Sharma, G Wang, Q Dong
Oxid Med Cell Longev, 2019-06-27;2019(0):2352079.  2019-06-27

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity
Authors: L Marcar, K Bardhan, L Gheorghiu, P Dinkelborg, H Pfäffle, Q Liu, M Wang, Z Piotrowska, LV Sequist, K Borgmann, JE Settleman, JA Engelman, AN Hata, H Willers
Cell Rep, 2019-06-18;27(12):3422-3432.e4.  2019-06-18

Exploring the kidney hazard of exposure to mercuric chloride in mice:Disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis
Authors: S Li, R Baiyun, Z Lv, J Li, D Han, W Zhao, L Yu, N Deng, Z Liu, Z Zhang
Chemosphere, 2019-06-17;234(0):822-829.  2019-06-17

Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells
Authors: A P, A K, S L, M M, M K
Toxicol Rep, 2019-06-15;6(0):556-563.  2019-06-15

Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis
Authors: HJ Wen, S Gao, Y Wang, M Ray, MA Magnuson, CVE Wright, MP Di Maglian, TL Frankel, HC Crawford
Cell Mol Gastroenterol Hepatol, 2019-05-21;0(0):.  2019-05-21

Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease
Authors: NM Shanbhag, MD Evans, W Mao, AL Nana, WW Seeley, A Adame, RA Rissman, E Masliah, L Mucke
Acta Neuropathol Commun, 2019-05-17;7(1):77.  2019-05-17

Canonical cytosolic iron-sulfur cluster assembly and non-canonical functions of DRE2 in Arabidopsis
Authors: X Wang, X Chen, L Sun, W Qian
PLoS Genet., 2019-04-29;15(4):e1008094.  2019-04-29

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
Authors: N Martinez-V, M Marigil, M García-Mou, M Gonzalez-H, JJ Aristu, LI Ramos-Garc, S Tejada, R Díez-Valle, A Patiño-Gar, OJ Becher, C Gomez-Manz, J Fueyo, MM Alonso
Acta Neuropathol Commun, 2019-04-29;7(1):64.  2019-04-29

Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms
Authors: A Chaiprason, Z Janjetovic, TK Kim, SG Jarrett, JA D'Orazio, MF Holick, EKY Tang, RC Tuckey, U Panich, W Li, AT Slominski
Redox Biol, 2019-04-20;24(0):101206.  2019-04-20

The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect
Authors: KC Wang, YC Liu, M El-Shazly, SP Shih, YC Du, YM Hsu, HY Lin, YC Chen, YC Wu, SC Yang, MC Lu
Int J Mol Sci, 2019-04-19;20(8):.  2019-04-19

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress
Authors: A Scaramozza, D Park, S Kollu, I Beerman, X Sun, DJ Rossi, CP Lin, DT Scadden, C Crist, AS Brack
Cell Stem Cell, 2019-04-18;0(0):.  2019-04-18

OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair
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Cancer Cell Int., 2019-04-15;19(0):99.  2019-04-15

MiR-34s negatively regulate homologous recombination through targeting RAD51
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Arch. Biochem. Biophys., 2019-04-02;666(0):73-82.  2019-04-02

Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma
Authors: M Cucè, ME Gallo Cant, MA Siciliano, C Riillo, D Caracciolo, F Scionti, N Staropoli, V Zuccalà, L Maltese, A Di Vito, K Grillone, V Barbieri, M Arbitrio, MT Di Martino, M Rossi, N Amodio, P Tagliaferr, P Tassone, C Botta
J Hematol Oncol, 2019-03-21;12(1):32.  2019-03-21

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
Authors: D Zhang, X Hu, J Li, J Liu, L Baks-Te Bu, M Wiersma, NU Malik, DMS van Marion, M Tolouee, F Hoogstra-B, EAH Lanters, AM van Roon, AAF de Vries, DA Pijnappels, NMS de Groot, RH Henning, BJJM Brundel
Nat Commun, 2019-03-21;10(1):1307.  2019-03-21

Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
Authors: S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou
Cell Death Dis, 2019-03-20;10(4):274.  2019-03-20

Neuroprotective effects of blueberry anthocyanins against perfluorooctanoic sulfonate on planarian Dugesia japonica
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Ecotoxicol. Environ. Saf., 2019-03-15;175(0):39-47.  2019-03-15

Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation
Authors: A Wilson, V Menon, Z Khan, A Alam, L Litovchick, V Yakovlev
Redox Biol, 2019-03-15;24(0):101169.  2019-03-15

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma
Authors: M Wu, Y Wang, D Yang, Y Gong, F Rao, R Liu, Y Danna, J Li, J Fan, J Chen, W Zhang, Q Zhan
EBioMedicine, 2019-03-12;0(0):.  2019-03-12

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy
Authors: MT Handley, K Reddy, J Wills, E Rosser, A Kamath, M Halachev, G Falkous, D Williams, P Cox, A Meynert, ES Raymond, H Morrison, S Brown, E Allan, I Aligianis, AP Jackson, BH Ramsahoye, A von Kriegs, RW Taylor, AJ Finch, DR FitzPatric
PLoS Genet., 2019-03-11;15(3):e1007605.  2019-03-11

Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway
Authors: J Wang, B Chan, M Tong, Y Paung, U Jo, D Martin, M Seeliger, J Haley, H Kim
PLoS Genet., 2019-02-21;15(2):e1007983.  2019-02-21

Molecular origin of AuNPs-induced cytotoxicity and mechanistic study
Authors: E Lee, H Jeon, M Lee, J Ryu, C Kang, S Kim, J Jung, Y Kwon
Sci Rep, 2019-02-21;9(1):2494.  2019-02-21

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes
Authors: S Lee, JY Lee, EW Lee, S Park, DH Kang, C Min, DJ Lee, D Kang, J Song, J Kwon, SW Kang
Cell Rep, 2019-02-19;26(8):2194-2211.e6.  2019-02-19

MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1
Authors: Y Dai, X Lin, W Xu, X Lin, Q Huang, L Shi, Y Pan, Y Zhang, Y Zhu, C Li, L Liu, S Zhang
Cell Death Dis, 2019-02-13;10(2):144.  2019-02-13

miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKC? and ZEB1 inhibition
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J. Exp. Clin. Cancer Res., 2019-02-04;38(1):51.  2019-02-04

PP2AC? deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells
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Int. J. Biochem. Cell Biol., 2019-01-30;109(0):40-58.  2019-01-30

PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
Authors: CG Li, C Mahon, NM Sweeney, E Verschuere, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitc
Cell Rep, 2019-01-29;26(5):1333-1343.e7.  2019-01-29

Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression
Authors: T Lin, TC Lin, DJ McGrail, PK Bhupal, YH Ku, W Zhang, L Meng, SY Lin, G Peng, RYL Tsai
Oncogene, 2019-01-28;0(0):.  2019-01-28

Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
Authors: FJ Chou, Y Chen, D Chen, Y Niu, G Li, P Keng, S Yeh, C Chang
EBioMedicine, 2019-01-26;0(0):.  2019-01-26

PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway
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J. Exp. Clin. Cancer Res., 2019-01-18;38(1):24.  2019-01-18

Molecular damage and responses of oral keratinocyte to hydrogen peroxide
Authors: KY Lin, CH Chung, JS Ciou, PF Su, PW Wang, DB Shieh, TC Wang
BMC Oral Health, 2019-01-11;19(1):10.  2019-01-11

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
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Nat Commun, 2019-01-08;10(1):87.  2019-01-08

Promotion of homology-directed DNA repair by polyamines
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Nat Commun, 2019-01-08;10(1):65.  2019-01-08

Epithelial?mesenchymal transition induced by bone morphogenetic protein 9 hinders cisplatin efficacy in ovarian cancer cells
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Mol Med Rep, 2019-01-03;0(0):.  2019-01-03

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
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Nat Commun, 2018-12-17;9(1):5351.  2018-12-17

Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro
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Ecotoxicol. Environ. Saf., 2018-11-02;168(0):378-387.  2018-11-02

DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
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Nat Commun, 2018-10-18;9(1):4342.  2018-10-18

Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy.
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Biomaterials, 2017-04-17;133(0):94-106.  2017-04-17

Development of a Test Method for the Evaluation of DNA Damage in Mouse Spermatogonial Stem Cells.
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Toxicol Res, 2017-04-15;33(2):107-118.  2017-04-15

miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells.
Authors: Huang S, Yang Z, Ma Y, Yang Y, Wang S
DNA Cell Biol, 2017-04-01;36(4):303-310.  2017-04-01

Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.
Authors: Ming J, Sun B, Li Z, Lin L, Meng X, Han B, Wang R, Wu P, Li J, Cai J, Jiang C
Aging (Albany NY), 2017-04-01;9(4):1233-1247.  2017-04-01

Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer.
Authors: Flaherty R, Owen M, Fagan-Murphy A, Intabli H, Healy D, Patel A, Allen M, Patel B, Flint M
Breast Cancer Res, 2017-03-24;19(1):35.  2017-03-24

Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice.
Authors: Chen W, Liu N, Zhang H, Zhang H, Qiao J, Jia W, Zhu S, Mao Z, Kang J
Cell Rep, 2017-03-21;18(12):2880-2892.  2017-03-21

RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.
Authors: Su C, Zhao H, Zhao Y, Ji H, Wang Y, Zhi L, Li X
Sci Rep, 2017-03-06;7(0):43897.  2017-03-06

Doxorubicin and vincristine affect undifferentiated rat spermatogonia.
Authors: Beaud H, van Pelt A, Delbes G
Reproduction, 2017-03-03;153(6):725-735.  2017-03-03

Stimulation of lactate receptor (HCAR1) affects cellular DNA repair capacity.
Authors: Wagner W, Kania K, Ciszewski W
DNA Repair (Amst), 2017-02-20;52(0):49-58.  2017-02-20

Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid.
Authors: Brachova P, Alvarez N, Van Voorhis B, Christenson L
Gynecol Oncol, 2017-02-16;145(3):577-583.  2017-02-16

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.
Authors: Ishida N, Nakagawa T, Iemura S, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K
Mol Cell Biol, 2017-02-01;37(4):.  2017-02-01

FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage.
Authors: Bigarella C, Li J, Rimmele P, Liang R, Sobol R, Ghaffari S
J Biol Chem, 2016-12-19;292(7):3005-3015.  2016-12-19

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.
Authors: Wang Y, An R, Umanah G, Park H, Nambiar K, Eacker S, Kim B, Bao L, Harraz M, Chang C, Chen R, Wang J, Kam T, Jeong J, Xie Z, Neifert S, Qian J, Andrabi S, Blackshaw S, Zhu H, Song H, Ming G, Dawson V, Dawson T
Science, 2016-10-07;354(6308):.  2016-10-07

Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols.
Authors: Behar R, Luo W, Lin S, Wang Y, Valle J, Pankow J, Talbot P
Tob Control, 2016-09-15;25(0):ii94-ii102.  2016-09-15

Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.
Authors: Santamaria Nunez G, Robles C, Giraudon C, Martinez-Leal J, Compe E, Coin F, Aviles P, Galmarini C, Egly J
Mol Cancer Ther, 2016-09-14;15(10):2399-2412.  2016-09-14

Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair.
Authors: Kaur S, Coulombe Y, Ramdzan Z, Leduy L, Masson J, Nepveu A
J Biol Chem, 2016-09-02;291(43):22769-22780.  2016-09-02

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.
Authors: Moureau S, Luessing J, Harte E, Voisin M, Lowndes N
Open Biol, 2016-09-01;6(9):.  2016-09-01

Amplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint.
Authors: Kim J, Anurag M, Veeraraghavan J, Schiff R, Li K, Wang X
Mol Cancer Res, 2016-08-03;14(10):920-927.  2016-08-03

DNA Damage Response and DNA Repair in Skeletal Myocytes From a Mouse Model of Spinal Muscular Atrophy.
Authors: Fayzullina S, Martin L
J Neuropathol Exp Neurol, 2016-07-24;75(9):889-902.  2016-07-24

Human CDK18 promotes replication stress signaling and genome stability.
Authors: Barone G, Staples C, Ganesh A, Patterson K, Bryne D, Myers K, Patil A, Eyers C, Maslen S, Skehel J, Eyers P, Collis S
Nucleic Acids Res, 2016-07-05;44(18):8772-8785.  2016-07-05

Overexpression of HPV16 E6* Alters beta-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells.
Authors: Evans W, Filippova M, Filippov V, Bashkirova S, Zhang G, Reeves M, Duerksen-Hughes P
Cancer Genomics Proteomics, 2016-07-01;13(4):259-73.  2016-07-01

HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells.
Authors: Sadik H, Korangath P, Nguyen N, Gyorffy B, Kumar R, Hedayati M, Teo W, Park S, Panday H, Munoz T, Menyhart O, Shah N, Pandita R, Chang J, Deweese T, Chang H, Pandita T, Sukumar S
Cancer Res, 2016-06-14;76(15):4443-56.  2016-06-14

Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells.
Authors: Kaushik Tiwari M, Adaku N, Peart N, Rogers F
Nucleic Acids Res, 2016-06-13;44(16):7742-54.  2016-06-13

PKCalpha and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation.
Authors: Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger M
Nucleic Acids Res, 2016-05-19;44(16):7630-45.  2016-05-19

Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.
Authors: Li Y, Armstrong R, Duronio R, MacAlpine D
Nucleic Acids Res, 2016-04-29;44(15):7204-18.  2016-04-29

NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer.
Authors: Li L, Reddy S, Lin Z, Liu S, Park H, Chun S, Bornmann W, Thibodeaux J, Yan J, Chakrabarti G, Xie X, Sumer B, Boothman D, Yordy J
Mol Cancer Ther, 2016-04-12;15(7):1757-67.  2016-04-12

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.
Authors: Ranes M, Boeing S, Wang Y, Wienholz F, Menoni H, Walker J, Encheva V, Chakravarty P, Mari P, Stewart A, Giglia-Mari G, Snijders A, Vermeulen W, Svejstrup J
Nucleic Acids Res, 2016-04-07;44(11):5246-55.  2016-04-07

A panel of in vitro tests to evaluate genotoxic and morphological neoplastic transformation potential on Balb/3T3 cells by pristine and remediated titania and zirconia nanoparticles.
Authors: Stoccoro A, Di Bucchianico S, Uboldi C, Coppede F, Ponti J, Placidi C, Blosi M, Ortelli S, Costa A, Migliore L
Mutagenesis, 2016-04-07;31(5):511-29.  2016-04-07

Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma.
Authors: Liu J, Sun X, Zhu H, Qin Q, Yang X, Sun X
J Biochem, 2016-03-31;160(4):195-204.  2016-03-31

HT-COMET: a novel automated approach for high throughput assessment of human sperm chromatin quality.
Authors: Albert O, Reintsch W, Chan P, Robaire B
Hum Reprod, 2016-03-13;31(5):938-46.  2016-03-13

Differences in quantification of DNA double-strand breaks assessed by 53BP1/gammaH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.
Authors: Kurashige T, Shimamura M, Nagayama Y
J Radiat Res, 2016-03-06;57(3):312-7.  2016-03-06

Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses.
Authors: Jacobs K, Misri S, Meyer B, Raj S, Zobel C, Sleckman B, Hallahan D, Sharma G
Mol Biol Cell, 2016-03-03;27(8):1332-45.  2016-03-03

Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.
Authors: Matsuda S, Matsuda Y, Yanagisawa S, Ikura M, Ikura T, Matsuda T
Toxicol Sci, 2016-02-28;151(2):224-35.  2016-02-28

Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.
Authors: McLaughlin D, Coey C, Yang W, Drohat A, Matunis M
J Biol Chem, 2016-02-25;291(17):9014-24.  2016-02-25

Effects of corexit oil dispersants and the WAF of dispersed oil on DNA damage and repair in cultured human bronchial airway cells, BEAS-2B.
Authors: Major D, Derbes R, Wang H, Roy-Engel A
Gene Rep, 2016-02-11;3(0):22-30.  2016-02-11

miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair.
Authors: Czochor J, Sulkowski P, Glazer P
Mol Cancer Res, 2016-02-05;14(4):363-73.  2016-02-05

Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation.
Authors: Hedayati M, Haffner M, Coulter J, Raval R, Zhang Y, Zhou H, Mian O, Knight E, Razavi N, Dalrymple S, Isaacs J, Santos A, Hales R, Nelson W, Yegnasubramanian S, Deweese T
Clin Cancer Res, 2016-02-01;22(13):3310-3319.  2016-02-01

Sequential Combination Therapy of CDK Inhibition and Doxorubicin Is Synthetically Lethal in p53-Mutant Triple-Negative Breast Cancer.
Authors: Jabbour-Leung N, Chen X, Bui T, Jiang Y, Yang D, Vijayaraghavan S, McArthur M, Hunt K, Keyomarsi K
Mol Cancer Ther, 2016-01-29;15(4):593-607.  2016-01-29

DNA double-strand break repair: a theoretical framework and its application.
Authors: Murray P, Cornelissen B, Vallis K, Chapman S
J R Soc Interface, 2016-01-27;13(114):20150679.  2016-01-27

The Opposing Actions of Arabidopsis CHROMOSOME TRANSMISSION FIDELITY7 and WINGS APART-LIKE1 and 2 Differ in Mitotic and Meiotic Cells.
Authors: De K, Bolanos-Villegas P, Mitra S, Yang X, Homan G, Jauh G, Makaroff C
Plant Cell, 2016-01-26;28(2):521-36.  2016-01-26

The Role of HMGB1 in Radioresistance of Bladder Cancer.
Authors: Shrivastava S, Mansure J, Almajed W, Cury F, Ferbeyre G, Popovic M, Seuntjens J, Kassouf W
Mol Cancer Ther, 2015-12-30;15(3):471-9.  2015-12-30

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.
Authors: Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O
Nucleic Acids Res, 2015-11-17;0(0):.  2015-11-17

UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation.
Authors: Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, Shiotani B, Matsumoto M, Nakayama K, Ogura H, Shiiya N, Kitagawa M
Mol Cell Biol, 2015-11-16;36(3):394-406.  2015-11-16

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.
Authors: Efimova E, Takahashi S, Shamsi N, Wu D, Labay E, Ulanovskaya O, Weichselbaum R, Kozmin S, Kron S
Mol Cancer Res, 2015-11-04;14(2):173-84.  2015-11-04

Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma.
Authors: Dai L, Trillo-Tinoco J, Cao Y, Bonstaff K, Doyle L, Del Valle L, Whitby D, Parsons C, Reiss K, Zabaleta J, Qin Z
Blood, 2015-11-03;126(26):2821-31.  2015-11-03

Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
Authors: Yu Z, Huang Y, Shieh S
Nucleic Acids Res, 2015-11-03;44(3):1133-50.  2015-11-03

Long-term exposure to diesel engine exhaust induces primary DNA damage: a population-based study.
Authors: Duan H, Jia X, Zhai Q, Ma L, Wang S, Huang C, Wang H, Niu Y, Li X, Dai Y, Yu S, Gao W, Chen W, Zheng Y
Occup Environ Med, 2015-10-21;73(2):83-90.  2015-10-21

c-Myc-miR-29c-REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma.
Authors: Luo H, Chen Z, Wang S, Zhang R, Qiu W, Zhao L, Peng C, Xu R, Chen W, Wang H, Chen Y, Yang J, Zhang X, Zhang S, Chen D, Wu W, Zhao C, Cheng G, Jiang T, Lu D, You Y, Liu N, Wang H
Brain, 2015-10-08;138(0):3654-72.  2015-10-08

Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells.
Authors: Xu H, Zhou X, Wen X, Lauer F, Liu K, Hudson L, Aleksunes L, Burchiel S
Toxicol Sci, 2015-10-05;149(1):31-41.  2015-10-05

Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages.
Authors: Garbati M, Hays L, Rathbun R, Jillette N, Chin K, Al-Dhalimy M, Agarwal A, Newell A, Olson S, Bagby G
J Leukoc Biol, 2015-10-02;99(3):455-65.  2015-10-02

Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.
Authors: Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B
J Biol Chem, 2015-10-01;290(48):28675-82.  2015-10-01

ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.
Authors: Yang H, Palmbos P, Wang L, Kim E, Ney G, Liu C, Prasad J, Misek D, Yu X, Ljungman M, Simeone D
J Biol Chem, 2015-09-17;290(45):27146-57.  2015-09-17

Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage.
Authors: Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M
J Biochem, 2015-09-15;159(2):225-37.  2015-09-15

MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Authors: Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, Seidman M, Greenberg R
Genes Dev, 2015-09-03;29(18):1955-68.  2015-09-03

Stem Cell-Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters.
Authors: Maruyama C, Leigh N, Nelson J, McCall A, Mellas R, Lei P, Andreadis S, Baker O
J Dent Res, 2015-08-18;94(11):1610-7.  2015-08-18

The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.
Authors: Fang X, Lin H, Wang X, Zuo Q, Qin J, Zhang P
Acta Biochim Biophys Sin (Shanghai), 2015-08-18;47(10):834-41.  2015-08-18

Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
Authors: Lin H, Ha K, Lu G, Fang X, Cheng R, Zuo Q, Zhang P
Mol Cell Biol, 2015-08-17;35(21):3657-68.  2015-08-17

Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
Authors: Torres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt C, Zhao Y, Lum L, Zaman A, Yeaman C, White M, Pandita T
Mol Cell Biol, 2015-08-17;35(21):3633-45.  2015-08-17

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.
Authors: Sperlazza J, Rahmani M, Beckta J, Aust M, Hawkins E, Wang S, Zu Zhu S, Podder S, Dumur C, Archer K, Grant S, Ginder G
Blood, 2015-08-11;126(12):1462-72.  2015-08-11

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.
Authors: Paquet N, Adams M, Leong V, Ashton N, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess J, Bolderson E, O'Byrne K, Richard D
Nucleic Acids Res, 2015-08-10;43(18):8817-29.  2015-08-10

Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.
Authors: Chen Y, Harris R, Hatahet Z, Chou K
Proc Natl Acad Sci U S A, 2015-08-03;112(33):E4556-64.  2015-08-03

CUX2 protein functions as an accessory factor in the repair of oxidative DNA damage.
Authors: Pal R, Ramdzan Z, Kaur S, Duquette P, Marcotte R, Leduy L, Davoudi S, Lamarche-Vane N, Iulianella A, Nepveu A
J Biol Chem, 2015-07-28;290(37):22520-31.  2015-07-28

PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.
Authors: Cheng X, Byrne M, Brown K, Konopleva M, Kornblau S, Bennett R, May W
Blood, 2015-07-22;126(13):1585-94.  2015-07-22

Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications.
Authors: Wang L, Meng D, Hao Y, Zhao Y, Li D, Zhang B, Zhang Y, Zhang Z
J Biomater Appl, 2015-07-21;30(5):547-57.  2015-07-21

YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.
Authors: Stachelek G, Peterson-Roth E, Liu Y, Fernandez R, Pike L, Qian J, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer P
Mol Cancer Res, 2015-06-26;13(10):1389-97.  2015-06-26

Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.
Authors: Morgan C, Diaz J, Zeitlin S, Gray D, Wells J
Proc Natl Acad Sci U S A, 2015-06-23;112(27):8344-9.  2015-06-23

USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance.
Authors: Lee J, Chang N, Yoon Y, Yang H, Cho H, Kim E, Shin Y, Kang W, Oh Y, Mun G, Joo K, Nam D, Lee J
Neuro Oncol, 2015-06-01;18(1):37-47.  2015-06-01

The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition.
Authors: Chatterjee P, Choudhary G, Alswillah T, Xiong X, Heston W, Magi-Galluzzi C, Zhang J, Klein E, Almasan A
Mol Cancer Ther, 2015-05-29;14(8):1896-906.  2015-05-29

Repair of DNA Damage Induced by the Cytidine Analog Zebularine Requires ATR and ATM in Arabidopsis.
Authors: Liu C, Finke A, Diaz M, Rozhon W, Poppenberger B, Baubec T, Pecinka A
Plant Cell, 2015-05-28;27(6):1788-800.  2015-05-28

Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.
Authors: Garcia J, Chen J, Guillory B, Donehower L, Smith R, Lamb D
Biol Reprod, 2015-05-27;93(1):24.  2015-05-27

Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
Authors: Liu G, Yang D, Rupaimoole R, Pecot C, Sun Y, Mangala L, Li X, Ji P, Cogdell D, Hu L, Wang Y, Rodriguez-Aguayo C, Lopez-Berestein G, Shmulevich I, De Cecco L, Chen K, Mezzanzanica D, Xue F, Sood A, Zhang W
J Natl Cancer Inst, 2015-05-20;107(7):.  2015-05-20

Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism.
Authors: Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J
Cancer Res, 2015-05-14;75(13):2663-73.  2015-05-14

Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity.
Authors: Butler K, Peeler D, Casey B, Dair B, Elespuru R
Mutagenesis, 2015-05-11;30(4):577-91.  2015-05-11

Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.
Authors: Goldstein M, Kastan M
Cancer Res, 2015-05-04;75(13):2699-707.  2015-05-04

PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.
Authors: Yuan Z, Guo W, Yang J, Li L, Wang M, Lei Y, Wan Y, Zhao X, Luo N, Cheng P, Liu X, Nie C, Peng Y, Tong A, Wei Y
J Biol Chem, 2015-04-27;290(24):14927-44.  2015-04-27

Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage.
Authors: Huang V, Lee C, Lee Y, Lam K, Ko J, Yeung W, Ho P, Chiu P
Mol Hum Reprod, 2015-04-09;21(6):516-26.  2015-04-09

2'-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF.
Authors: Shen W, Liang X, Sun H, Crooke S
Nucleic Acids Res, 2015-04-08;43(9):4569-78.  2015-04-08

A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation.
Authors: Hatano K, Kumar B, Zhang Y, Coulter J, Hedayati M, Mears B, Ni X, Kudrolli T, Chowdhury W, Rodriguez R, Deweese T, Lupold S
Nucleic Acids Res, 2015-04-06;43(8):4075-86.  2015-04-06

DNA strand breaks, acute phase response and inflammation following pulmonary exposure by instillation to the diesel exhaust particle NIST1650b in mice.
Authors: Kyjovska Z, Jacobsen N, Saber A, Bengtson S, Jackson P, Wallin H, Vogel U
Mutagenesis, 2015-03-14;30(4):499-507.  2015-03-14

A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
Authors: Nicolae C, Aho E, Choe K, Constantin D, Hu H, Lee D, Myung K, Moldovan G
Nucleic Acids Res, 2015-03-09;43(6):3143-53.  2015-03-09

BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
Authors: Ge C, Che L, Ren J, Pandita R, Lu J, Li K, Pandita T, Du C
Proc Natl Acad Sci U S A, 2015-03-02;112(11):E1210-9.  2015-03-02

Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks.
Authors: Matsuoka K, Iimori M, Niimi S, Tsukihara H, Watanabe S, Kiyonari S, Kiniwa M, Ando K, Tokunaga E, Saeki H, Oki E, Maehara Y, Kitao H
Mol Cancer Ther, 2015-02-19;14(4):1004-13.  2015-02-19

Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.
Authors: Verhalen B, Justice J, Imperiale M, Jiang M
J Virol, 2015-02-18;89(9):5032-9.  2015-02-18

Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery.
Authors: Buckel L, Savariar E, Crisp J, Jones K, Hicks A, Scanderbeg D, Nguyen Q, Sicklick J, Lowy A, Tsien R, Advani S
Cancer Res, 2015-02-13;75(7):1376-1387.  2015-02-13

Replication fork integrity and intra-S phase checkpoint suppress gene amplification.
Authors: Kondratova A, Watanabe T, Marotta M, Cannon M, Segall A, Serre D, Tanaka H
Nucleic Acids Res, 2015-02-11;43(5):2678-90.  2015-02-11

Inhibiting protein arginine deiminases has antioxidant consequences.
Authors: Witalison E, Cui X, Hofseth A, Subramanian V, Causey C, Thompson P, Hofseth L
J Pharmacol Exp Ther, 2015-01-29;353(1):64-70.  2015-01-29

Nuclear GIT2 is an ATM substrate and promotes DNA repair.
Authors: Lu D, Cai H, Park S, Siddiqui S, Premont R, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon C, Martin B, Maudsley S
Mol Cell Biol, 2015-01-20;35(7):1081-96.  2015-01-20

53BP1 promotes microhomology-mediated end-joining in G1-phase cells.
Authors: Xiong X, Du Z, Wang Y, Feng Z, Fan P, Yan C, Willers H, Zhang J
Nucleic Acids Res, 2015-01-13;43(3):1659-70.  2015-01-13

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.
Authors: Iyama T, Lee S, Berquist B, Gileadi O, Bohr V, Seidman M, McHugh P, Wilson D
Nucleic Acids Res, 2014-12-10;43(1):247-58.  2014-12-10

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.
Authors: Sanij E, Diesch J, Lesmana A, Poortinga G, Hein N, Lidgerwood G, Cameron D, Ellul J, Goodall G, Wong L, Dhillon A, Hamdane N, Rothblum L, Pearson R, Haviv I, Moss T, Hannan R
Genome Res, 2014-12-01;25(2):201-12.  2014-12-01

BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.
Authors: Qi W, Wang R, Chen H, Wang X, Xiao T, Boldogh I, Ba X, Han L, Zeng X
J Cell Sci, 2014-11-13;128(2):317-30.  2014-11-13

The RASSF1A tumor suppressor regulates XPA-mediated DNA repair.
Authors: Donninger H, Clark J, Rinaldo F, Nelson N, Barnoud T, Schmidt M, Hobbing K, Vos M, Sils B, Clark G
Mol Cell Biol, 2014-11-03;35(1):277-87.  2014-11-03

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Authors: Lu E, McLellan M, Ding L, Fulton R, Mardis E, Wilson R, Miller C, Westervelt P, DiPersio J, Link D, Walter M, Ley T, Graubert T
Blood, 2014-10-27;124(26):3887-95.  2014-10-27

PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway.
Authors: Chandra A, Lin T, Zhu J, Tong W, Huo Y, Jia H, Zhang Y, Liu X, Cengel K, Xia B, Qin L
J Biol Chem, 2014-10-21;290(1):157-67.  2014-10-21

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.
Authors: Abu-Odeh M, Salah Z, Herbel C, Hofmann T, Aqeilan R
Proc Natl Acad Sci U S A, 2014-10-20;111(44):E4716-25.  2014-10-20

Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.
Authors: Sobinoff A, Sutherland J, Beckett E, Stanger S, Johnson R, Jarnicki A, McCluskey A, St John J, Hansbro P, McLaughlin E
Hum Reprod, 2014-09-30;29(12):2719-35.  2014-09-30

Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-kappaB pathway.
Authors: Aguilera-Aguirre L, Bacsi A, Radak Z, Hazra T, Mitra S, Sur S, Brasier A, Ba X, Boldogh I
J Immunol, 2014-09-29;193(9):4643-53.  2014-09-29

Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.
Authors: Martinez T, Phillips J, Karanja K, Polaczek P, Wang C, Li B, Campbell J, Dervan P
Nucleic Acids Res, 2014-09-23;42(18):11546-59.  2014-09-23

Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.
Authors: Alli E, Solow-Cordero D, Casey S, Ford J
Cancer Res, 2014-09-12;74(21):6205-15.  2014-09-12

HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs.
Authors: Vernin C, Thenoz M, Pinatel C, Gessain A, Gout O, Delfau-Larue M, Nazaret N, Legras-Lachuer C, Wattel E, Mortreux F
Cancer Res, 2014-09-09;74(21):6082-93.  2014-09-09

Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells.
Authors: Qin Q, Xie H, Wise S, Browning C, Thompson K, Holmes A, Wise J
Toxicol Sci, 2014-08-30;142(1):117-25.  2014-08-30

The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness.
Authors: Thangavel C, Boopathi E, Ciment S, Liu Y, O'Neill R, Sharma A, McMahon S, Mellert H, Addya S, Ertel A, Birbe R, Fortina P, Dicker A, Knudsen K, Den R
Clin Cancer Res, 2014-08-27;20(21):5468-5482.  2014-08-27

Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells.
Authors: Wakasugi M, Sasaki T, Matsumoto M, Nagaoka M, Inoue K, Inobe M, Horibata K, Tanaka K, Matsunaga T
J Biol Chem, 2014-08-27;289(41):28730-7.  2014-08-27

Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy.
Authors: Artesi M, Kroonen J, Bredel M, Nguyen-Khac M, Deprez M, Schoysman L, Poulet C, Chakravarti A, Kim H, Scholtens D, Seute T, Rogister B, Bours V, Robe P
Neuro Oncol, 2014-08-25;17(3):392-406.  2014-08-25

Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci.
Authors: Kines K, Sokolowski M, deHaro D, Christian C, Belancio V
Nucleic Acids Res, 2014-08-20;42(16):10488-502.  2014-08-20

Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
Authors: Cleaver J, Brennan-Minnella A, Swanson R, Fong K, Chen J, Chou K, Chen Y, Revet I, Bezrookove V
Proc Natl Acad Sci U S A, 2014-08-18;111(37):13487-92.  2014-08-18

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
Authors: Lancini C, van den Berk P, Vissers J, Gargiulo G, Song J, Hulsman D, Serresi M, Tanger E, Blom M, Vens C, van Lohuizen M, Jacobs H, Citterio E
J Exp Med, 2014-08-11;211(9):1759-77.  2014-08-11

Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates.
Authors: Zhang R, Yang J, Sima M, Zhou Y, Kopecek J
Proc Natl Acad Sci U S A, 2014-08-04;111(33):12181-6.  2014-08-04

Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency.
Authors: Avagyan S, Churchill M, Yamamoto K, Crowe J, Li C, Lee B, Zheng T, Mukherjee S, Zha S
Blood, 2014-07-29;124(10):1622-5.  2014-07-29

Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the beta-adrenoceptor/cAMP/protein kinase A axis during oxidative stress.
Authors: Brunyanszki A, Olah G, Coletta C, Szczesny B, Szabo C
Mol Pharmacol, 2014-07-28;86(4):450-62.  2014-07-28

Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes.
Authors: Wei L, Griego A, Chu M, Ozbun M
Carcinogenesis, 2014-07-26;35(10):2373-81.  2014-07-26

NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas.
Authors: Cho H, Wang W, Jhaveri N, Lee D, Sharma N, Dubeau L, Schonthal A, Hofman F, Chen T
Mol Cancer Ther, 2014-07-03;13(8):2004-17.  2014-07-03

CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.
Authors: Shibata E, Dar A, Dutta A
J Biol Chem, 2014-06-24;289(33):23056-64.  2014-06-24

ATM regulates NF-kappaB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment.
Authors: Fang L, Choudhary S, Zhao Y, Edeh C, Yang C, Boldogh I, Brasier A
Nucleic Acids Res, 2014-06-23;42(13):8416-32.  2014-06-23

RhoB promotes gammaH2AX dephosphorylation and DNA double-strand break repair.
Authors: Mamouni K, Cristini A, Guirouilh-Barbat J, Monferran S, Lemarie A, Faye J, Lopez B, Favre G, Sordet O
Mol Cell Biol, 2014-06-09;34(16):3144-55.  2014-06-09

Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.
Authors: Sutherland J, Fraser B, Sobinoff A, Pye V, Davidson T, Siddall N, Koopman P, Hime G, McLaughlin E
Biol Reprod, 2014-05-01;90(5):92.  2014-05-01

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.
Authors: Bolderson E, Petermann E, Croft L, Suraweera A, Pandita R, Pandita T, Helleday T, Khanna K, Richard D
Nucleic Acids Res, 2014-04-20;42(10):6326-36.  2014-04-20

Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells.
Authors: Li D, Cao W
Am J Physiol Gastrointest Liver Physiol, 2014-04-03;306(10):G863-72.  2014-04-03

Human papillomavirus type 16 E6* induces oxidative stress and DNA damage.
Authors: Williams V, Filippova M, Filippov V, Payne K, Duerksen-Hughes P
J Virol, 2014-04-02;88(12):6751-61.  2014-04-02

USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.
Authors: Knobel P, Belotserkovskaya R, Galanty Y, Schmidt C, Jackson S, Stracker T
Mol Cell Biol, 2014-03-31;34(11):2062-74.  2014-03-31

Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.
Authors: Scanlon S, Glazer P
Mol Cancer Res, 2014-03-31;12(7):1016-28.  2014-03-31

Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways.
Authors: Garcia K, Blank J, Bouck D, Liu X, Sappal D, Hather G, Cosmopoulos K, Thomas M, Kuranda M, Pickard M, Liu R, Bandi S, Smith P, Lightcap E
Mol Cancer Ther, 2014-03-26;13(6):1625-35.  2014-03-26

Dynamic regulation of Rad51 by E2F1 and p53 in prostate cancer cells upon drug-induced DNA damage under hypoxia.
Authors: Wu M, Wang X, McGregor N, Pienta K, Zhang J
Mol Pharmacol, 2014-03-13;85(6):866-76.  2014-03-13

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair.
Authors: Morales J, Richard P, Rommel A, Fattah F, Motea E, Patidar P, Xiao L, Leskov K, Wu S, Hittelman W, Chiang C, Manley J, Boothman D
Nucleic Acids Res, 2014-03-03;42(8):4996-5006.  2014-03-03

Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
Authors: Nathanson D, Armijo A, Tom M, Li Z, Dimitrova E, Austin W, Nomme J, Campbell D, Ta L, Le T, Lee J, Darvish R, Gordin A, Wei L, Liao H, Wilks M, Martin C, Sadeghi S, Murphy J, Boulos N, Phelps M, Faull K, Herschman H, Jung M, Czernin J, Lavie A, Radu C
J Exp Med, 2014-02-24;211(3):473-86.  2014-02-24

The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress.
Authors: Lee M, Wang L, Chang Z
Nucleic Acids Res, 2014-02-21;42(8):4972-84.  2014-02-21

Speckle-type POZ protein, SPOP, is involved in the DNA damage response.
Authors: Zhang D, Wang H, Sun M, Yang J, Zhang W, Han S, Xu B
Carcinogenesis, 2014-01-22;35(8):1691-7.  2014-01-22

Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.
Authors: Boichuk S, Lee D, Mehalek K, Makielski K, Wozniak A, Seneviratne D, Korzeniewski N, Cuevas R, Parry J, Brown M, Zewe J, Taguchi T, Kuan S, Schoffski P, Debiec-Rychter M, Duensing A
Cancer Res, 2014-01-02;74(4):1200-13.  2014-01-02

Low and high linear energy transfer radiation sensitization of HCC cells by metformin.
Authors: Kim E, Kim M, Cho C, Jung W, Jeong Y, Jeong J
J Radiat Res, 2013-12-28;55(3):432-42.  2013-12-28

LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.
Authors: Lehle S, Hildebrand D, Merz B, Malak P, Becker M, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O
Nucleic Acids Res, 2013-12-26;42(6):e41.  2013-12-26

The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.
Authors: Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung T, Laslett A, Willam C, Qin B, Maxwell P, Esteban M
J Biol Chem, 2013-12-26;289(6):3339-51.  2013-12-26

Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.
Authors: Karst A, Jones P, Vena N, Ligon A, Liu J, Hirsch M, Etemadmoghadam D, Bowtell D, Drapkin R
Cancer Res, 2013-12-23;74(4):1141-52.  2013-12-23

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.
Authors: Gatti L, Cossa G, Tinelli S, Carenini N, Arrighetti N, Pennati M, Cominetti D, de Cesare M, Zunino F, Zaffaroni N, Perego P
J Pharmacol Exp Ther, 2013-12-17;348(3):360-71.  2013-12-17

Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
Authors: Kim S, Jo S, Lee H, Kim T, Kim I, Yim J, Chung H
Anticancer Res, 2013-12-01;33(12):5445-51.  2013-12-01

Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
Authors: Proia D, Zhang C, Sequeira M, Jimenez J, He S, Spector N, Shapiro G, Tolaney S, Nagai M, Acquaviva J, Smith D, Sang J, Bates R, El-Hariry I
Clin Cancer Res, 2013-10-30;20(2):413-24.  2013-10-30

Potential new mechanisms of placental damage in celiac disease: anti-transglutaminase antibodies impair human endometrial angiogenesis.
Authors: Di Simone N, De Spirito M, Di Nicuolo F, Tersigni C, Castellani R, Silano M, Maulucci G, Papi M, Marana R, Scambia G, Gasbarrini A
Biol Reprod, 2013-10-17;89(4):88.  2013-10-17

Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle.
Authors: Dimitrov S, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston D
Genes Dev, 2013-10-15;27(20):2274-91.  2013-10-15

hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
Authors: Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J
Mol Cell Biol, 2013-10-14;33(24):4960-70.  2013-10-14

Intracellular deoxyribonucleotide pool imbalance and DNA damage in cells treated with hydroxyurea, an inhibitor of ribonucleotide reductase.
Authors: Osterman Golkar S, Czene S, Gokarakonda A, Haghdoost S
Mutagenesis, 2013-09-27;28(6):653-60.  2013-09-27

A hormone-DNA repair circuit governs the response to genotoxic insult.
Authors: Goodwin J, Schiewer M, Dean J, Schrecengost R, de Leeuw R, Han S, Ma T, Den R, Dicker A, Feng F, Knudsen K
Cancer Discov, 2013-09-11;3(11):1254-71.  2013-09-11

Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.
Authors: Lee H, Yoon C, Schmidt B, Park D, Zhang A, Erkizan H, Toretsky J, Kirsch D, Yoon S
Mol Cancer Ther, 2013-08-21;12(11):2591-600.  2013-08-21

EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
Authors: Pfaffle H, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes C, Sequist L, Zou L, Willers H
Cancer Res, 2013-08-21;73(20):6254-63.  2013-08-21

Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.
Authors: Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan A, Boulton S, Ganesan S
J Biol Chem, 2013-08-06;288(45):32357-69.  2013-08-06

XPD-dependent activation of apoptosis in response to triplex-induced DNA damage.
Authors: Kaushik Tiwari M, Rogers F
Nucleic Acids Res, 2013-08-02;41(19):8979-94.  2013-08-02

Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.
Authors: Weeks L, Fu P, Gerson S
Mol Cancer Ther, 2013-07-19;12(10):2248-60.  2013-07-19

Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.
Authors: Song H, Hedayati M, Hobbs R, Shao C, Bruchertseifer F, Morgenstern A, Deweese T, Sgouros G
Mol Cancer Ther, 2013-07-19;12(10):2043-54.  2013-07-19

Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose).
Authors: Wei L, Nakajima S, Hsieh C, Kanno S, Masutani M, Levine A, Yasui A, Lan L
J Cell Sci, 2013-07-18;126(0):4414-23.  2013-07-18

DNA damage in normally and prematurely aged mice.
Authors: Maslov A, Ganapathi S, Westerhof M, Quispe-Tintaya W, White R, Van Houten B, Reiling E, Dolle M, van Steeg H, Hasty P, Hoeijmakers J, Vijg J
Aging Cell, 2013-04-24;12(3):467-77.  2013-04-24

Thirdhand smoke causes DNA damage in human cells.
Authors: Hang B, Sarker A, Havel C, Saha S, Hazra T, Schick S, Jacob P, Rehan V, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel L
Mutagenesis, 2013-03-05;28(4):381-91.  2013-03-05

Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
Authors: Yang Y, Durando M, Smith-Roe S, Sproul C, Greenwalt A, Kaufmann W, Oh S, Hendrickson E, Vaziri C
Nucleic Acids Res, 2013-01-07;41(4):2296-312.  2013-01-07

Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.
Authors: Sayers C, Papandreou I, Guttmann D, Maas N, Diehl J, Witze E, Koong A, Koumenis C
Mol Pharmacol, 2012-12-10;83(3):594-604.  2012-12-10

Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
Authors: Trinh B, Ko S, Barengo N, Lin S, Naora H
Cancer Res, 2012-12-07;73(2):1000-10.  2012-12-07

CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma.
Authors: Subramanian C, Hada M, Opipari A, Castle V, Kwok R
Mol Cancer Res, 2012-12-05;11(2):173-81.  2012-12-05

Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer.
Authors: Ziebarth A, Nowsheen S, Steg A, Shah M, Katre A, Dobbin Z, Han H, Lopez-Berestein G, Sood A, Conner M, Yang E, Landen C
Clin Cancer Res, 2012-11-12;19(1):170-82.  2012-11-12

A novel role of Kruppel-like factor 8 in DNA repair in breast cancer cells.
Authors: Lu H, Hu L, Li T, Lahiri S, Shen C, Wason M, Mukherjee D, Xie H, Yu L, Zhao J
J Biol Chem, 2012-10-26;287(52):43720-9.  2012-10-26

Radioprotective properties of tocopherol succinate against ionizing radiation in mice.
Authors: Singh V, Singh P, Wise S, Posarac A, Fatanmi O
J Radiat Res, 2012-10-03;54(2):210-20.  2012-10-03

DNA damage in human skin keratinocytes caused by multiwalled carbon nanotubes with carboxylate functionalization.
Authors: McShan D, Yu H
Toxicol Ind Health, 2012-09-25;30(6):489-98.  2012-09-25

Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
Authors: Cerniglia G, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, Koumenis C, Maity A
Mol Pharmacol, 2012-09-18;82(6):1230-40.  2012-09-18

Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development.
Authors: Verduzco D, Dovey J, Shukla A, Kodym E, Skaug B, Amatruda J
Mol Cancer Res, 2012-09-17;10(11):1451-61.  2012-09-17

Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.
Authors: Yaseen A, Chen S, Hock S, Rosato R, Dent P, Dai Y, Grant S
Mol Pharmacol, 2012-08-24;82(6):1030-41.  2012-08-24

Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer.
Authors: Yuan S, Hou M, Hsieh Y, Huang C, Lee Y, Chen Y, Lo S
J Natl Cancer Inst, 2012-08-22;104(19):1485-502.  2012-08-22

Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
Authors: Nguyen C, Possemato R, Bauerlein E, Xie A, Scully R, Hahn W
Mol Cell Biol, 2012-07-30;32(19):3963-77.  2012-07-30

Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells.
Authors: Haro K, Scott A, Scheinberg D
Blood, 2012-07-24;120(10):2087-97.  2012-07-24

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G.
Authors: Wijesinghe P, Bhagwat A
Nucleic Acids Res, 2012-07-13;40(18):9206-17.  2012-07-13

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-beta.
Authors: Hardee M, Marciscano A, Medina-Ramirez C, Zagzag D, Narayana A, Lonning S, Barcellos-Hoff M
Cancer Res, 2012-06-12;72(16):4119-29.  2012-06-12

BCL2 suppresses PARP1 function and nonapoptotic cell death.
Authors: Dutta C, Day T, Kopp N, van Bodegom D, Davids M, Ryan J, Bird L, Kommajosyula N, Weigert O, Yoda A, Fung H, Brown J, Shapiro G, Letai A, Weinstock D
Cancer Res, 2012-06-11;72(16):4193-203.  2012-06-11

Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration.
Authors: Swa H, Blackstock W, Lim L, Gunaratne J
Mol Cell Proteomics, 2012-04-16;11(8):381-93.  2012-04-16

RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes.
Authors: Kujjo L, Ronningen R, Ross P, Pereira R, Rodriguez R, Beyhan Z, Goissis M, Baumann T, Kagawa W, Camsari C, Smith G, Kurumizaka H, Yokoyama S, Cibelli J, Perez G
Biol Reprod, 2012-03-19;86(3):76.  2012-03-19

(212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease.
Authors: Yong K, Milenic D, Baidoo K, Brechbiel M
Mol Cancer Ther, 2012-01-11;11(3):639-48.  2012-01-11

Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication.
Authors: Baer A, Austin D, Narayanan A, Popova T, Kainulainen M, Bailey C, Kashanchi F, Weber F, Kehn-Hall K
J Biol Chem, 2012-01-05;287(10):7399-410.  2012-01-05

Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Authors: Kanai R, Rabkin S, Yip S, Sgubin D, Zaupa C, Hirose Y, Louis D, Wakimoto H, Martuza R
J Natl Cancer Inst, 2011-12-15;104(1):42-55.  2011-12-15

Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair.
Authors: Song L, Dai T, Xie Y, Wang C, Lin C, Wu Z, Ying Z, Wu J, Li M, Li J
J Mol Cell Biol, 2011-12-08;4(2):108-17.  2011-12-08

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.
Authors: Meng F, Evans J, Bhupathi D, Banica M, Lan L, Lorente G, Duan J, Cai X, Mowday A, Guise C, Maroz A, Anderson R, Patterson A, Stachelek G, Glazer P, Matteucci M, Hart C
Mol Cancer Ther, 2011-12-06;11(3):740-51.  2011-12-06

Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
Authors: Lee AY, Chiba T, Truong LN
J. Biol. Chem., 2011-11-28;287(4):2531-43.  2011-11-28

A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest.
Authors: Feng Z, Zhang J
Nucleic Acids Res, 2011-09-27;40(2):726-38.  2011-09-27

Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells.
Authors: Reelfs O, Macpherson P, Ren X, Xu Y, Karran P, Young A
Nucleic Acids Res, 2011-09-02;39(22):9620-32.  2011-09-02

BID Binds to Replication Protein A and Stimulates ATR Function following Replicative Stress.
Authors: Liu Y, Vaithiyalingam S, Shi Q
Mol. Cell. Biol., 2011-08-22;31(21):4298-309.  2011-08-22

Paternal DNA damage resulting from various sperm treatments persists after fertilization and is similar before and after DNA replication.
Authors: Yamauchi Y, Riel J, Ward M
J Androl, 2011-05-05;33(2):229-38.  2011-05-05

Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Authors: Boichuk S, Hu L, Hein J
J. Virol., 2010-06-02;84(16):8007-20.  2010-06-02

The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
Authors: Petit I, Karajannis MA, Vincent L, Young L, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S
Blood, 2007-11-16;111(4):1951-61.  2007-11-16

Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
Gut, 2006-07-13;56(2):243-52.  2006-07-13