CP 122721 hydrochloride
Chemical Name: (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride
Purity: ≥98%
Biological Activity
CP 122721 hydrochloride is a high affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets.
Gonsalves et al.
Eur.J.Pharmacol., 1996;305:181 -
Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats.
Auais et al.
Am.J.Physiol. Lung Cell Mol.Physiol., 2003;285:L105 -
Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor.
McLean et al.
J.Pharmacol.Exp.Ther., 1996;277:900
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