Home / NK1 Receptor Antagonists / CP 99994 dihydrochloride

CP 99994 dihydrochloride

Catalog #: 3417
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3417/10
3417/50
CP 99994 dihydrochloride | CAS No. 145148-39-6 | NK1 Receptor Antagonists
1 Image
Description: High affinity NK1 antagonist

Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride

Purity: ≥99%

Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Technical Data

M.Wt:
369.33
Formula:
C19H24N2O.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
145148-39-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CP 99994 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CP 99994 dihydrochloride include:

7 Citations: Showing 1 - 7

  1. Role of perivascular nerve and sensory neurotransmitter dysfunction in inflammatory bowel disease.
    Authors: Craig L Et al.
    Am J Physiol Heart Circ Physiol  2021;320:H1887-H1902
  2. nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice.
    Authors: Christina T Et al.
    Elife  2020;9
  3. The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch.
    Authors: Sheahan Et al.
    J.Neurosci  2020;40:8816
  4. N-benzhydryl quinuclidine compounds are a potent and Src kinase-independent inhibitor of NALCN channels.
    Authors: Suyun Et al.
    Br J Pharmacol  2020;177:3795-3810
  5. Crystal structure of the human NK1 tachykinin receptor.
    Authors: Yin Et al.
    Proc.Natl.Acad.Sci.U.S.A.  2018;115:13264
  6. Differential Gene Expression Profile in the Rat Caudal Vestibular Nucleus is Associated with Individual Differences in Motion Sickness Susceptibility.
    Authors: Wei Et al.
    PLoS One  2015;10:e0124203
  7. Novel dynamic measures of emetic behavior in musk shrews.
    Authors: Horn Et al.
    Nature  2013;179:60

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CP 99994 dihydrochloride

There are currently no reviews for this product. Be the first to review CP 99994 dihydrochloride and earn rewards!

Have you used CP 99994 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.