CRANAD 2
Chemical Name: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
Purity: ≥98%
Biological Activity
CRANAD 2 is a near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits.
Ran et al.
J.Am.Chem.Soc., 2009;131:15257 -
Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.
Ran et al.
PLoS One., 2011;6:e19362
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