CX 614
Chemical Name: 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one
Purity: ≥99%
Biological Activity
CX 614 is an AMPAkine; positive allosteric modulator of AMPA. Prototypical benzamide which occupies subsite A only. Modulates channel deactivation and desensitization.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy.
Harms et al.
Neuropharmacology, 2013;64:45 -
Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Timm et al.
Mol.Pharmacol., 2011;80:267 -
Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators.
Hennegriff et al.
J.Neurochem., 1997;68:2424
Product Datasheets
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Citations for CX 614
The citations listed below are publications that use Tocris products. Selected citations for CX 614 include:
3 Citations: Showing 1 - 3
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A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength.
Authors: Ege T Et al.
Cell Rep 2021;36:109467
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Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway.
Authors: Susumu Et al.
iScience 2021;24:102504
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Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish.
Authors: Carolina da Silveira Et al.
Elife 2021;10
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