Cyclopamine
Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Purity: ≥97%
Biological Activity
Cyclopamine is an inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo. Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.
Bar et al.
Stem Cells, 2007;25:2524 -
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells.
D'Amour et al.
Nat.Biotechnol., 2006;24:1392 -
Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened.
Chen et al.
Genes Dev., 2002;16:2743 -
Cancer: a twist in a hedgehog's tale.
Scott
Nature, 2003;425:780
Product Datasheets
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Citations for Cyclopamine
The citations listed below are publications that use Tocris products. Selected citations for Cyclopamine include:
8 Citations: Showing 1 - 8
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Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy.
Authors: Atzmon Et al.
Front Mol Neurosci 2018;11:336
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Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish.
Authors: Yan Et al.
Sci Rep 2017;7:45796
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Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells.
Authors: Rodrigues
PNAS 2017;114(12):3139
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Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation.
Authors: Yuan Et al.
Stem Cells Int 2016;7:11024
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Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
Authors: Kumar Et al.
Elife 2015;4
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Sonic hedgehog produced by bone marrow-derived mesenchymal stromal cells supports cell survival in myelodysplastic syndrome.
Authors: Zou Et al.
Sci Signal 2015;2015:957502
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White-to-brown metabolic conversion of human adipocytes by JAK inhibition.
Authors: Moisan Et al.
Nat Cell Biol 2015;17:57
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GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas.
Authors: Atwood Et al.
Nat Commun 2013;494:484
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