Cyclopiazonic acid

Catalog #: 1235
16 Citations Datasheet / COA / SDS

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Cyclopiazonic acid | CAS No. 18172-33-3 | Ca2+-ATPase Inhibitors

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Description: Inhibitor of SERCA ATPase

Alternative Names: α-Cyclopiazonic acid

Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one

Purity: ≥98%

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Product Details

Citations (16)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cyclopiazonic acid is a cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca²⁺-ATPase.

Technical Data

M.Wt:

336.39

Formula:

C₂₀H₂₀N₂O₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

18172-33-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Cyclopiazonic acid effect on Ca²⁺-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover.
Soler et al.
Biochemistry, 1998;37:4266
Comparison of contractions produced by CB, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle.
Takemoto et al.
Br.J.Pharmacol., 1998;124:1449
On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca²⁺-ATPases by cyclopiazonic acid.
Plenge-Tellechea et al.
J.Biol.Chem., 1997;272:2794

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Citations for Cyclopiazonic acid

The citations listed below are publications that use Tocris products. Selected citations for Cyclopiazonic acid include:

16 Citations: Showing 1 - 10

The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
Authors: Dwivedi Et al.
Eur J Pharmacol 2023;
IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca²⁺ to Lysosomes.
Authors: Atakpa Et al.
Cell Rep 2018;25:3180
Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes.
Authors: Morais Et al.
Front Mol Neurosci 2018;10:444
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Neuron 2017;95:531
Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated Ins secretion.
Authors: Li Et al.
Cell Death Dis 2016;7:e2275
Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
Authors: Elgueta Et al.
Neuropharmacology 2015;9:6
Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.
Authors: Zhu Et al.
Am J Physiol Cell Physiol 2015;308:C608
Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
Authors: Fransen Et al.
J Neurosci 2015;10:e0121634
Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging.
Authors: McQuail Et al.
Cardiovasc Res 2013;70:63
Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca²⁺ release channels.
Authors: Alzayady Et al.
J Biol Chem 2013;288:11122

Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
Authors: Earls Et al.
Front Cell Neurosci 2010;30:15843

Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.
Authors: Grey and Burrell
J Neurophysiol 2010;103:2737

Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
Authors: Choi Et al.
PLoS One 2009;82:324

Mobilization of calcium from intracellular stores facilitates somatodendritic DA release.
Authors: Patel Et al.
J Neurosci 2009;29:6568

Calcium signals can freely cross the nuclear envelope in hippocampal neurons: somatic calcium increases generate nuclear calcium transients.
Authors: Eder and Bading
BMC Neurosci 2007;8:57

Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores.
Authors: Kumar and Foster
J Neurophysiol 2004;91:2437

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