Cyclopiazonic acid
1 Image
Description: Inhibitor of SERCA ATPase
Alternative Names: α-Cyclopiazonic acid
Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
Purity: ≥98%
Biological Activity
Cyclopiazonic acid is a cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.Technical Data
M.Wt:
336.39
Formula:
C20H20N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
18172-33-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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GPN does not release lysosomal Ca2+, but evokes ER Ca2+ release by increasing cytosolic pH independent of cathepsin C
P Atakpa, LM van Marrew, M Apta-Smith, S Chakrabort, CW Taylor
J. Cell. Sci., 2019;0(0):. -
IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes
P Atakpa, NB Thillaiapp, S Mataragka, DL Prole, CW Taylor
Cell Rep, 2018;25(11):3180-3193.e7. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1
J Neurosci, 2016;36(18):5055-70. -
Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover.
Soler et al.
Biochemistry, 1998;37:4266 -
Comparison of contractions produced by CB, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle.
Takemoto et al.
Br.J.Pharmacol., 1998;124:1449 -
On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid.
Plenge-Tellechea et al.
J.Biol.Chem., 1997;272:2794
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Citations for Cyclopiazonic acid
The citations listed below are publications that use Tocris products. Selected citations for Cyclopiazonic acid include:
16 Citations: Showing 1 - 10
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The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
Authors: Dwivedi Et al.
Eur J Pharmacol 2023;
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IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes.
Authors: Atakpa Et al.
Cell Rep 2018;25:3180
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Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes.
Authors: Morais Et al.
Front Mol Neurosci 2018;10:444
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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Authors: Chai Et al.
Neuron 2017;95:531
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Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated Ins secretion.
Authors: Li Et al.
Cell Death Dis 2016;7:e2275
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Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
Authors: Elgueta Et al.
Neuropharmacology 2015;9:6
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Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.
Authors: Zhu Et al.
Am J Physiol Cell Physiol 2015;308:C608
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Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
Authors: Fransen Et al.
J Neurosci 2015;10:e0121634
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Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging.
Authors: McQuail Et al.
Cardiovasc Res 2013;70:63
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Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.
Authors: Alzayady Et al.
J Biol Chem 2013;288:11122
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Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
Authors: Earls Et al.
Front Cell Neurosci 2010;30:15843
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Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases.
Authors: Grey and Burrell
J Neurophysiol 2010;103:2737
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Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
Authors: Choi Et al.
PLoS One 2009;82:324
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Mobilization of calcium from intracellular stores facilitates somatodendritic DA release.
Authors: Patel Et al.
J Neurosci 2009;29:6568
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Calcium signals can freely cross the nuclear envelope in hippocampal neurons: somatic calcium increases generate nuclear calcium transients.
Authors: Eder and Bading
BMC Neurosci 2007;8:57
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Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores.
Authors: Kumar and Foster
J Neurophysiol 2004;91:2437
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