CYM 5442 hydrochloride
Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride
Purity: ≥98%
Biological Activity
CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Janes K, Little J, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, Neumann W, Salvemini D
J Biol Chem, 2014;289(30):21082-97. -
Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions
Gonzalez-Cabrera et al.
Mol.Pharmacol., 2008;74:1308
Product Datasheets
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Citations for CYM 5442 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:
6 Citations: Showing 1 - 6
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Two distinct trophectoderm lineage stem cells from human pluripotent stem cells.
Authors: Balaji M Et al.
J Biol Chem 2021;296:100386
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Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Authors: H?bner Et al.
Nat Commun 2018;9:4860
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Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
Authors: Masato Et al.
Cell 2018;174:636-648.e18
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2.
Authors: Chumanevich Et al.
Mediators Inflamm 2016;2016:1503206
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Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
Authors: Li Et al.
J Neuroinflammation 2015;12:70
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The development and maintenance of PacT.-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Authors: Janes Et al.
J Biol Chem 2014;289:21082
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