D-AP4
Chemical Name: D-(-)-2-Amino-4-phosphonobutyric acid
Purity: ≥98%
Biological Activity
D-AP4 is a broad spectrum excitatory amino acid receptor antagonist. Also agonist at the quisqualate-sensitized AP6 site in hippocampus where it is less potent than L-AP4.DL Mixture and L-isomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Br.J.Pharmacol., 1982;75:65 -
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378 -
Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for D-AP4
The citations listed below are publications that use Tocris products. Selected citations for D-AP4 include:
3 Citations: Showing 1 - 3
-
Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
Authors: France
Neuropharmacology 2017;112:76
-
G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
Authors: Sexton and Gelder
PLoS One 2015;10:e0128690
-
Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype.
Authors: Sexton Et al.
Neural Dev 2015;10:17
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for D-AP4
There are currently no reviews for this product. Be the first to review D-AP4 and earn rewards!
Have you used D-AP4?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
