Home / Ghrelin Receptor Antagonists / [D-Lys3]-GHRP-6

[D-Lys3]-GHRP-6

Catalog #: 1922
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1922/5
[D-Lys3]-GHRP-6
1 Image
Description: Ghrelin receptor antagonist
Product Details
Citations (6)
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Biological Activity

[D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.

Technical Data

M.Wt:
930.12
Formula:
C49H63N13O6
Sequence:
HWKWFK

(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)

Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
136054-22-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for [D-Lys3]-GHRP-6

The citations listed below are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:

6 Citations: Showing 1 - 6

  1. Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus.
    Authors: Murtuza and Isokawa
    J Neurochem  2018;144:58
  2. Rikkunshito prevents PacT.-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.
    Authors: Kamei Et al.
    PLoS One  2017;12:e0171819
  3. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
    Authors: Hashiguchi
    PLoS One  2017;12(9):e0184261
  4. The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice.
    Authors: Gomez and
    Alcohol Clin Exp Res  2014;38:2436
  5. Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion.
    Authors: Song Et al.
    PLoS One  2013;8:e65422
  6. Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats.
    Authors: Kemp Et al.
    PLoS Comput Biol  2011;57:633

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