Dexamethasone

Biological Activity

Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Long-term culture of genome-stable bipotent stem cells from adult human liver.
   Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen M, Ellis E, van Wenum M, Fuchs S, de Ligt J, van de Wetering M, Sasaki N, Boers S, Kemperman H, de Jonge J, Ijzermans J, Nieuwenhuis E, Hoekstra R, Strom S, Vries R, van der Laan L, Cuppen E, Clevers H
   Cell, 2015;160(1):299-312.
2. Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells.
   Matasic et al.
   J.Leukoc.Biol., 1999;66:909
3. Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy.
   Laane et al.
   Cell Death Differ., 2009;16:1018
4. Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig.
   Teixeira et al.
   Br.J.Pharmacol., 1996;118:317
5. Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell.
   Sittichokechaiwut et al.
   Eur.Cell Mater., 2010;20:45
6. The effect of dexamethasone on lentiviral vector infection is associated with importin α.
   Deng et al.
   Biomed.Rep., 2014;2:137
7. Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.
   Seregin et al.
   Mol.Ther., 2009;17:685

Product Datasheets